Delayed voluntary exercise does not enhance cognitive performance after hippocampal injury : an investigation of differentially distributed exercise protocols
Elise Wogensen, Marie Gajhede Gram, Jens Bak Sommer, Christina Rytter Vilsen, Jesper Mogensen, Hana Malá
언어
영어(ENG)
URL
https://www.earticle.net/Article/A286377
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원문정보
초록
영어
Voluntary exercise has previously been shown to enhance cognitive recovery after acquired brain injury (ABI). The present study evaluated effects of two differentially distributed protocols of delayed, voluntary exercise on cognitive recovery using an allocentric place learning task in an 8-arm radial maze. Fifty-four Wistar rats were subjected to either bilateral transection of the fimbria-fornix (FF) or to sham surgery. Twen-ty-one days postinjury, the animals started exercising in running wheels either for 14 consecutive days (FF/exercise daily [ExD], sham/ExD) or every other day for 14 days (FF/exercise every second day [ExS], sham/ExS). Additional groups were given no exercise treatment (FF/not exer-cise [NE], sham/NE). Regardless of how exercise was distributed, we found no cognitively enhancing effects of exercise in the brain injured animals. Design and protocol factors possibly affecting the efficacy of post-ABI exercise are discussed.
목차
Abstract INTRODUCTION MATERIALS AND METHODS Subjects and experimental groups Voluntary exercise in running wheels Allocentric place learning task in 8-arm radial maze Surgery Histology Statistics analysis RESULTS Anatomy Body weights during exercise Running wheel exercise Behavior DISCUSSION CONFLICTS OF INTEREST ACKNOWLEDGMENTS REFERENCES