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Effects of Myrrh Extracts on Collagenase Activity and Procollagen Synthesis in Hs68 Human Fibroblasts and Tyrosinase Activity
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- 발행기관
- 보안공학연구지원센터(IJUNESST) 바로가기
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- 간행물
- International Journal of u- and e- Service, Science and Technology 바로가기
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- 통권
- Vol.9 No.4 (2016.04)바로가기
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- 페이지
- pp.145-154
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- 저자
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- 언어
- 영어(ENG)
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- URL
- https://www.earticle.net/Article/A273315
※ 원문제공기관과의 협약기간이 종료되어 열람이 제한될 수 있습니다.
원문정보
초록
- 영어
- This study was designed to investigate the collagen metabolism and tyrosinase activity of Myrrh Extracts (ME). The currently known effects of ME are to move blood, calm pain, solve edema, and promote tissue regeneration. The effect of ME on type I procollagen production and collagenase (matrix metalloproteinase-1, henceforth referred as MMP-1) activity in human normal fibroblasts Hs68 after ultraviolet B (UVB, 312 nm) irradiation was measured using the ELISA method. The tyrosinase activity after treatment with ME was measured as well. There was no cytotoxicity at all tested concentrations. ME significantly inhibited the increased collagenase activity after UVB damage, whereas it did not recover the reduced type I procollagen production in UVB damaged Hs68 cells. It did not reduce the L-DOPA oxidation. However, it significantly reduced the tyrosinase activity. In conclusion, ME showed the anti-wrinkle effects via the collagenase inhibitory mechanism and whitening effects via the tyrosinase inhibitory mechanism. Although further research is needed to validate its efficacy, these results suggest that ME may have potential as an anti-aging ingredient in cosmetic herb markets.
목차
Abstract
1. Introduction
2. Methods
2.1. Sample Preparation
2.2. Reagents
2.3. Cell culture
2.4. UVB Irradiation
2.5. Cell Viability
2.6. Assays of Collagen Type I Synthesis and Collagenase Inhibition
2.7. Tyrosinase Inhibition Assay
2.8. Inhibition of L-DOPA Oxidation
2.9. Statistical Analysis
3. Results
3.1. Cytotoxicity on Hs68 Human Fibroblasts
3.2. Assay of Collagen Type I Synthesis
3.3. Assay of Collagenase Activity
3.4. Inhibitory Effects on Tyrosinase Activity
3.5. Inhibitory Effects on L-DOPA Oxidation
4. Discussion
5. Conclusions
Acknowledgments
References
키워드
Myrrh type I procollagen collagenase tyrosinase저자
간행물 정보
발행기관
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- 발행기관명
- 보안공학연구지원센터(IJUNESST) [Science & Engineering Research Support Center, Republic of Korea(IJUNESST)]
- 설립연도
- 2006
- 분야
- 공학>컴퓨터학
- 소개
- 1. 보안공학에 대한 각종 조사 및 연구 2. 보안공학에 대한 응용기술 연구 및 발표 3. 보안공학에 관한 각종 학술 발표회 및 전시회 개최 4. 보안공학 기술의 상호 협조 및 정보교환 5. 보안공학에 관한 표준화 사업 및 규격의 제정 6. 보안공학에 관한 산학연 협동의 증진 7. 국제적 학술 교류 및 기술 협력 8. 보안공학에 관한 논문지 발간 9. 기타 본 회 목적 달성에 필요한 사업
간행물
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- 간행물명
- International Journal of u- and e- Service, Science and Technology
- 간기
- 격월간
- pISSN
- 2005-4246
- 수록기간
- 2008~2016
- 십진분류
- KDC 505 DDC 605
이 권호 내 다른 논문 / International Journal of u- and e- Service, Science and Technology Vol.9 No.4
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