Earticle

초록

영어

Skin is the largest organ of the human body, which surrounds and protects body from external environments. Skin is divided in epidermis and dermis layer, and especially, epidermis is composed three layers each known as spinous, granular and cornified layer. Though various cell types constitute epidermis such as melanocytes, keratinocytes and langerhans cells, over 95% of epidermis consists of keratinocytes. As differentiation arise, the major component of epidermis, keratinocytes gradually proceed differentiated state from cell cycle. The differentiation of keratinocytes is the most important functional role in formation of stratum corneum, thus protects body from microbial invasion and inhibits hydration of skin. Due to diverse function of skin biology, keratinocytes has been studied mainly in pathology about toxicology, chemicals, and cosmetology. Alpha-mangostin (α-mangostin) is a yellow colored agent, which is the first xanthone isolated from Garcinia mangostana (mangosteen). According to previous study, α-mangostin has biological effects such as anti-inflammation and antioxidant properties. The aim of this study was to investigate how α-mangostin promotes calcium induced differentiation of human epidermal keratinocytes, HaCaTs, and improves gloss of the nail.

목차

Abstract
 Ⅰ. 서론
 Ⅱ. 연구방법
  1. 세포배양 및 시료처리
  2. 세포생존율 측정
  3. Quantitative real-time PCR
  4. 인체 적용 시험 설계
  5. 피시험자의 선정
  6. 알파망고스틴 함유 화장료의 제조
  7. 손톱윤기 측정
  8. 통계처리
 Ⅲ. 연구결과 및 고찰
  1. α-mangostin의 세포독성 분석
  2. 염화칼슘이 유도하는 세포분화표지인자의 유전자 발현에 α-mangostin이 미치는 효과
  3. α-mangostin의 손톱 윤기개선 효과
 Ⅳ. 결론
 참고문헌

키워드

저자

• 고정민 [ Jung-Min Ko | 서정대학교 뷰티아트과, (주)한국피부임상과학연구소 ]
• 한송희 [ Song Hee Han | 건국대학교 의학전문대학원 피부과학교실 ]
• 안규중 [ Kyu Joong Ahn | 건국대학교 의학전문대학원 피부과학교실 ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  대한피부미용학회지 [Korean Journal of Aesthetics and Cosmetology]

• 간기

  격월간

• pISSN

  1738-4567

• 수록기간

  2003~2015

• 십진분류

  KDC 593 DDC 646