Earticle

초록

영어

Bee venom, also known as apitoxin, is a bitter colorless liquid, which has a quite stability in temperature. It has been used for many years in traditional therapy as relieve pain and treat inflammatory. The skin goes change due to aging by environmental factors, divided in to intrinsic and extrinsic. ultraviolet (UV), one of extrinsic factor, is known as a main inducer of skin aging. Especially, UVB reported that lead to DNA damage, sun burn, and ROS creation. In this study, researcher investigated that whether bee venom affects to aging manifestations, such as wrinkle, sagging, skin tone, and evenness. To evaluate efficacy on aging skin phenomena, clinical efficacy trials were conducted using Antera 3D, Robo skin analyzer CS50, KONG PC Camera, and spectrophotometer. Improvement of wrinkle, sagging, and skin evenness were assessed using ANTERA 3D. Robo skin analyzer CS50 and spectrophotometer assessed improvement of skin tone. KONG PC Camera used to measuring facial keratinized cell. Measurements were taken three times, namely, before application, immediately after treatment, and 1 week after treatment. Through cellular efficacy trials, using human dermal fibroblasts (HDFs), researchers verified that bee venom has protective effects on UVB induced gene expression of MMP1 and COL1A1, which known as extracellular matrix (ECM) regulated genes. In conclusion, bee venom improves UVB-induced cellular damage, including ECM regulated gene expression, and aged skin manifestations. These results suggest bee venom as a new, effective anti-aging cosmetic ingredient.

목차

Abstract
 Ⅰ. 서론
 Ⅱ. 연구방법
  1. 시약 처리
  2. 진피섬유아세포 구입 및 배양
  3. 진피섬유아세포 자외선 조사
  4. 세포생존율 조사
  5. Quantitative real-time PCR
  6. 피시험자의 선정
  7. 인체 적용 시험 설계
  8. 정제봉독 함유 화장료의 제조
  9. 안면피부 측정 및 분석
  10. 유해사례에 대한 상시 평가
  11. 통계처리
 Ⅲ. 연구결과 및 고찰
  1. 정제봉독의 세포독성 분석
  2. 정제봉독에 의한 유전자발현 변화 분석
  3. 피시험자의 선정
  4. 눈가 주름 깊이 분석
  5. 볼광대 리프팅 분석
  6. 피부톤 분석
  7. 피부결 분석
  8. 안면 홍반 분석
  9. 각질 개선도 분석
  10. 피부이상 반응 평가
 Ⅳ. 결론
 참고문헌

키워드

저자

• 최춘설 [ Chun Seol Choi | 서경대학교 미용예술학과 ]
• 박진규 [ Jin Kyu Park | (주)비센 ]
• 안창기 [ Chang Gi An | (주)비센 ]
• 이은희 [ Eun Hee Lee | 서경대학교 미용예술학과 ]
• 안규중 [ Kyu Joong Ahn | 건국대학교 의학전문대학원 피부과학교실 ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  대한피부미용학회지 [Korean Journal of Aesthetics and Cosmetology]

• 간기

  격월간

• pISSN

  1738-4567

• 수록기간

  2003~2015

• 십진분류

  KDC 593 DDC 646