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Effects of Olibanum Extracts on Collagenase Activity and Procollagen Synthesis in Hs68 Human Fibroblasts and Tyrosinase Activity
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- 발행기관
- 보안공학연구지원센터(IJBSBT) 바로가기
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- 간행물
- International Journal of Bio-Science and Bio-Technology SCOPUS 바로가기
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- 통권
- Vol.7 No.5 (2015.10)바로가기
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- 페이지
- pp.127-134
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- 저자
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- 언어
- 영어(ENG)
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- URL
- https://www.earticle.net/Article/A255658
※ 원문제공기관과의 협약기간이 종료되어 열람이 제한될 수 있습니다.
원문정보
초록
- 영어
- This study was designed to investigate the collagen metabolism and tyrosinase activity of Olibanum extracts (OE). The currently known effects of OE are to move blood, calm pain, solve oedema, and promote tissue regeneration. The effect of OE on type I procollagen production and collagenase (matrix metalloproteinase-1, henceforth referred as MMP-1) activity in human normal fibroblasts Hs68 after ultraviolet B (UVB, 312 nm) irradiation was measured by the ELISA method. The tyrosinase activity after treatment with OE was measured as well. There was no cytotoxicity at all tested concentrations. OE significantly inhibited the increased collagenase activity after UVB damage, whereas it did not recover the reduced type I procollagen production in UVB damaged Hs68 cells. It did not reduce the tyrosinase activity and the L-DOPA oxidation, either. In conclusion, OE showed the anti-wrinkle effects via the collagenase inhibitory mechanism. Although further research is needed to validate its efficacy, these results suggest that OE may have potential as an anti-aging ingredient in cosmetic herb markets.
목차
Abstract
1. Introduction
2. Methods
2.1. Sample Preparation
2.2. Reagents
2.3. Cell Culture
2.4. UVB Irradiation
2.5. Cell Viability
2.6. Assays of Collagen Type I Synthesis and Collagenase Inhibition
2.7. Tyrosinase Inhibition Assay
2.8. Inhibition of L-DOPA Oxidation
2.9. Statistical Analysis
3. Results
3.1. Cytotoxicity on Hs68 Human Fibroblasts
3.2. Assay of Collagen Type I Synthesis
3.3. Assay of Collagenase Activity
3.4. Inhibitory Effects on Tyrosinase Activity
3.5. Inhibitory Effects on L-DOPA Oxidation
4. Discussion
5. Conclusions
Acknowledgments
References
키워드
Olibanum type I procollagen collagenase tyrosinase저자
간행물 정보
발행기관
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- 발행기관명
- 보안공학연구지원센터(IJBSBT) [Science & Engineering Research Support Center, Republic of Korea(IJBSBT)]
- 설립연도
- 2006
- 분야
- 공학>컴퓨터학
- 소개
- 1. 보안공학에 대한 각종 조사 및 연구 2. 보안공학에 대한 응용기술 연구 및 발표 3. 보안공학에 관한 각종 학술 발표회 및 전시회 개최 4. 보안공학 기술의 상호 협조 및 정보교환 5. 보안공학에 관한 표준화 사업 및 규격의 제정 6. 보안공학에 관한 산학연 협동의 증진 7. 국제적 학술 교류 및 기술 협력 8. 보안공학에 관한 논문지 발간 9. 기타 본 회 목적 달성에 필요한 사업
간행물
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- 간행물명
- International Journal of Bio-Science and Bio-Technology
- 간기
- 격월간
- pISSN
- 2233-7849
- 수록기간
- 2009~2016
- 등재여부
- SCOPUS
- 십진분류
- KDC 505 DDC 605
이 권호 내 다른 논문 / International Journal of Bio-Science and Bio-Technology Vol.7 No.5
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