Earticle

초록

영어

In order to analyze the anti-inflammatory effects of Centella asiatica (C. asiatica), which is effective in wound healing, blood circulation acceleration, fine line prevention, itchiness, and sedation, this study analyzed its anti-inflammatory effects in the macrophage of RAW264.7 mouse, and to find out its effects in scalp erythema improvement through clinical study, 11 people seen with scalp erythema were selected and conducted the study for a month from May 1~31, 2014. Study objects were divided into the experiment group using C. asiatica extract and comparison group not using C. asiatica and were instructed to spray about 2 mL twice a week, in the morning and at night, and their scalps were magnified 80 times using microscope (KONG PC Camera, Bomtech, Korea) and examined before experiment, 2 weeks later, and 4 weeks later. To analyze the anti-inflammatory effects of C. asiatica extract, RAW 264.7 cells were cultured in 37°C chamber at 5% CO2, and they were subcultured every 3 days to be processed for the same time with LPS. Cytotoxicity analysis was performed to find the proper concentration of C. asiatica extract, and the inflammatory factor, LPS 0.5 μg/mL was processed at 0 mg/mL, 0.01 mg/mL, 0.1 mg/mL, 1 mg/mL when processed at 1mg/mL the C. asiatica extract displayed 1.48 times the suppressive effect and was confirmed for anti-inflammatory effect. Clinical experiment was conducted to study the improvement effects of C. asiatica extract on scalp erythema on the experimental group using C. asiatica extract and the comparison group not using it, The improvement in the control group due to VES was 0.00 after 2 weeks and –6.67 after 4 weeks, which means that there was no improvement of erythema, and did not show a significant difference with over p<.05. Experiment group displayed the improvement rate of 33.33 after 2 weeks and 92.67 after 4 weeks; they displayed a great improvement of scalp erythema and displayed a significant difference with below p<.05. C. asiatica extract if released. Such results would influence in scalp improvement products, lead to more clinical studies using other various extracts for scalp improvements to contribute the development and utilization of scalp care products.

목차

Abstract
 Ⅰ. 서론
 Ⅱ. 이론적 배경
  1. 두피 손상 원인
  2. 스트레스로 인한 두피 질환
  3. C. asiatica
 Ⅲ. 연구방법
  1. C. asiatica 추출물 제조
  2. 마우스 대식세포주 모델에서 항염 효능 분석
  3. 인체적용시험
 Ⅳ. 연구결과 및 고찰
  1. 세포주 실험모델에서 C. asiatica 추출물의 항염 효능
  2. 인체적용시험
 Ⅴ. 결론
 참고문헌

키워드

저자

• 조춘희 [ Chun-Hee Jo | 건국대학교 산업대학원 향장학과 ]
• 김수연 [ Soo-Yeon Kim | 두원공과대학교 뷰티아트과 ]
• 안인숙 [ In-Sook An | 건국대학교 산업대학원 향장학과, 건국대학교 한국피부임상과학연구소 ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  대한피부미용학회지 [Korean Journal of Aesthetics and Cosmetology]

• 간기

  격월간

• pISSN

  1738-4567

• 수록기간

  2003~2015

• 십진분류

  KDC 593 DDC 646