Earticle

초록

영어

Exercise has beneficial effect on cancer apoptosis and benign prostatic hyperplasia (BPH). The BH3 interacting domain death agonist (BID) gene expression is associated with apoptosis or cell proliferation. In this study, we investigated the association between BID single nucleotide poly-morphisms (SNPs) and the development, prostate volume, and interna-tional prostate symptom score (IPSS) of BPH. In 222 BPH males and 214 controls, two SNPs in BID [rs8190315 (Ser56Gly), and rs2072392 (As-p106Asp)] were genotyped and analyzed using multiple logistic regres-sion models. In the result, the genotype and allele frequencies of rs8190315 and rs2072392 were not associated with BPH development or IPSS, however, the allele frequencies [odd ratio (OR)=1.90, 95% confi-dence interval (CI)=1.07-3.41, P=0.03] and genotype frequencies (in dominant model, OR=1.94, 95% CI=1.01-3.74, P=0.42) of rs8190315, and the genotype frequencies of rs2072392 (in dominant model, OR=1.94, 95% CI=1.01-3.74, P=0.42) were associated with increased prostate volume. We propose that rs8190315 and rs2072392 of BID may contrib-ute to the disease severity of BPH.

목차

Abstract
 INTRODUCTION
 MATERIALS AND METHODS
  Study subjects
  SNP selection and genotyping
  Statistical analysis
 RESULTS
 DISCUSSION
 CONFLICT OF INTEREST
 ACKNOWLEDGMENTS
 REFERENCES

키워드

저자

• Hosik Seok [ Department of Pharmacology and Kohwang Medical Research Institute, School of Medicine, Kyung Hee University, Seoul, Korea ]
• Su Kang Kim [ Department of Pharmacology and Kohwang Medical Research Institute, School of Medicine, Kyung Hee University, Seoul, Korea ]
• Koo Han Yoo [ Department of Urology, Collage of Medicine, Kyung Hee University, Seoul, Korea ]
• Byung-Cheol Lee [ Department of Internal Medicine, College of Oriental Medicine, Kyung Hee University, Seoul, Korea ]
• Young Ock Kim [ Herbal Crop Utilization Research Team, Department of Medicinal Crop Research Institute, National Institute of Horticulture & Herbal Science, Rural Administration, Eumseong, Korea ]
• Joo-Ho Chung [ Department of Pharmacology and Kohwang Medical Research Institute, School of Medicine, Kyung Hee University, Seoul, Korea ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  JER [Journal of Exercise Rehabilitation]

• 간기

  격월간

• pISSN

  2288-176X

• eISSN

  2288-1778

• 수록기간

  2013~2026

• 등재여부

  SCOPUS,KCI 등재

• 십진분류

  KDC 517 DDC 613