Earticle

초록

영어

This study was carried out to investigate the effects of the Achyrantes japonica (A. japonica) extract on serum level of hormones from osteo-porosis induced ovariectomized rats. Two month-old rats were ovariec-tomized (OVX), remained untreated for 8 weeks, and were subsequently administered A. japonica (300 mg/kg) every day for 8 weeks. We exam-ined the effects of treated A. japonica every 10 days on ovariectomy-re-lated changes in Insulin-like Growth Factors (IGF), Insulin-like Growth Factor binding protein-3 (IGBF-3), Estrogen, Calcium, and Phosporus. After 8 weeks, the serum levels of IGF-I, -II, and IGFBP-3 were higher presented as compared to the other two groups (P<0.05), in the A. ja-ponica extract treatment on OVX rats. Bone alkaline phosphatase levels were increased through A. japonica extract treatment in OVX rats com-pared to the other two groups. There were no differences between OVX and A. japonica extract treated OVX rats in serum levels of estrogen, but estrogen levels for the sham group were higher than for the other two groups. A. japonica extract is increased to serum levels of IGFs and IGFBP-3 of osteoporosis induced by ovariectomized rats. Thus, the re-sults reveal that the A. japonica extract is a possible role for improve-ment of osteoporosis induced-ovariectomized rats and has a great po-tential as an alternative tool for the treatment of osteoporosis.

목차

Abstract
 INTRODUCTION
 MATERIALS AND METHODS
  Experimental animals
  Collection of blood and tissue samples
  Measurement of IGF-1 and IGFBP-3 levels in growth plates
  Measurement of serum IGF-1 and IGFBP-3 levels
  IGFBP-3, estrogen, Ca++ and P assay
  Measurement of femur/body weight
  Statistical analysis
 RESULT
  Animal model
  Effect of ovariectomy and A. japonica on serum IGF-I levels
  Effect of ovariectomy and A. japonica on serum IGF-II levels
  Effect of ovariectomy and A. japonica on serum IGFBP-3 and estrogen levels
  Effect of ovariectomy and A. japonica on serum Ca++ and P levels
  Femur/body weight after A. japonica treatment in osteoporosis induced OVX rats.
 DISCUSSION
 CONFLICT OF INTEREST
 ACKNOWLEDGMENTS
 REFERENCES

키워드

저자

• Jin-sung Kim [ Department of Medicinal Crop Research Institute, National Institute of Horticultural & Herbal Science, Rural Development Administration, Eumseong-gun, Chungcheongbuk-do, Korea ]
• Sang-Won Lee [ Department of Medicinal Crop Research Institute, National Institute of Horticultural & Herbal Science, Rural Development Administration, Eumseong-gun, Chungcheongbuk-do, Korea ]
• Su-Kang Kim [ Kohwang Medical Research Institute, School of Medicine, Kyung Hee University, Seoul, Korea ]
• Sae-Won Na [ College of Veterinary Medicine, Chonbuk National University, Jeonju, Korea ]
• Young-Ock Kim [ Department of Medicinal Crop Research Institute, National Institute of Horticultural & Herbal Science, Rural Development Administration, Eumseong-gun, Chungcheongbuk-do, Korea ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  JER [Journal of Exercise Rehabilitation]

• 간기

  격월간

• pISSN

  2288-176X

• eISSN

  2288-1778

• 수록기간

  2013~2026

• 등재여부

  SCOPUS,KCI 등재

• 십진분류

  KDC 517 DDC 613