Earticle

초록

영어

Animal-derived placenta extract (PE) are available commercially and regularly used in various ointments and lotions for the purpose of improving skin properties. Although the effects of PE have been largely studied, only a few scientific studies report the skin safety evaluations of PE derived from animals such as pig. The objective of this study was to evaluated the anti-aging potential and safety of collagen in subcritical extract of porcine homogenate of placenta (SPE) for nutricosmetic and cosmeceutical ingredients. The experimental animals were divided into 6 groups, and were treated for 12 wks: positive control group (PO) treated with no-ultra violet (UV)B, negative control group (NO) treated with only UVB, experimental group 1 (OSPE-1) low dosage oral application treated with SPE, experimental group 2 (OSPE-2) high dosage oral application treated with SPE, experimental group 3 (OSPE-1+FSPE-1) low dosage oral and topical application treated with SPE, and experimental group 4 (OSPE-2+FSPE-2) high dosage oral and topical application treated with SPE. The serum biochemical markers for liver, aspartate aminotransferase (AST), and alanine aminotransferase (ALT) were also not affected by the application of SPE at any groups. But OSPE-2+FSPE-2 had significant (p<.05) decreased in lactate dehydrogenase (LDH) level compared than NO. The skin safety was performed to evaluate of potential toxicity using the primary irritation test and skin sensitization test. The SPE did not show any adverse reactions such as erythema and edema on intact skin sites at primary irritation test, but on abraded sites, some experimental animals showed very slight erythema. So, the SPE was classified as a practically non-irritating material based on the score 0.48 of primary irritation index. The skin sensitization study was tested by the guinea pig maximization test (GPMT) and Freund’s complete adjuvant (FCA) with intradermal injection of SPE. The skin sensitization test showed no skin sensitization. Based on this study, the potential for SPE a nutricosmetic and cosmeceutical ingredients were proven.

목차

Abstract
 Ⅰ. 서 론
 Ⅱ. 연구방법
  1. 시약
  2. 실험재료
  3. 실험동물의 사육조건
  4. UVB 조사 및 돼지태반추출물의 처치
  5. 몸무게, 장기 무게의 측정 및 혈액 분석
  6. 1차 피부자극 시험
  7. 피부감작성 시험
  8. 통계방법
 Ⅲ. 연구결과 및 고찰
  1. 체중 및 식이섭취량
  2. 장기무게
  3. 혈액학적 검사
  4. 일반 중독증상 평가
  5. 1차 피부자극의 평가
  6. 피부감작성 평가
 Ⅳ. 결론
 참고문헌

키워드

저자

• 홍양희 [ Yang-Hee Hong | 수원여자대학교 미용예술과 ]
• 정은영 [ Eun Young Jung | 전주대학교 가정교육과 ]
• 서형주 [ Hyung Joo Suh | 고려대학교 식품영양학과 ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  대한피부미용학회지 [Korean Journal of Aesthetics and Cosmetology]

• 간기

  격월간

• pISSN

  1738-4567

• 수록기간

  2003~2015

• 십진분류

  KDC 593 DDC 646