Earticle

초록

영어

Although a number of depigmenting agents have already been developed, the majority of them produce adverse side-effects. There is, therefore, a constant need for melanogenesis inhibitors. In this study, the hydrodistilled essential oil from the apricot seeds (Armeniacae Semen) was investigated for the activity against tyrosinase and melanogenesis. The apricot seed essential oil inhibited mushroom tyrosinase with an IC50 value of 1.11 μg/mL, which is more potent than the activities of kojic acid (IC50 5.07 μg/mL), ascorbic acid (IC50 54.0 μg/mL) and lemon essential oil (IC50 432.8 μg/mL). Benzaldehyde, the major component of the apricot seed essential oil, also showed similar level of inhibition (IC50 0.94 μg/mL). These results suggest that the activity of the apricot seed essential oil is due to benzaldehyde. The apricot seed essential oil decreased tyrosinase activity and melanin content of murine B16F10 melanoma cells in concentration-depentent manners. No cytotoxic effect was seen in B16F10 and human CCD-1064sk skin fibroblast cells treated with up to 100 μg/mL of the apricot seed essential oil. These results indicate that the apricot seed essential oil may have potential for the application in aromatherapy and the development of depigmenting agents.

목차

Abstract
 Ⅰ. 서론
 Ⅱ. 연구방법
  1. 정유 추출
  2. 세포배양
  3. Mushroom tyrosinase 저해 활성 측정
  4. Cell-free tyrosinase 저해 활성 측정
  5. 멜라닌 생성 저해 활성 측정
  6. 세포 독성 측정
 Ⅲ. 연구결과 및 고찰
  1. 행인 정유의 버섯 티로시나제 저해
  2. Cell-free tyrosinase 저해
  3. 멜라닌 생성 저해
  4. 세포 독성
 Ⅳ. 결론
 참고문헌

키워드

저자

• 안정현 [ Jeong-Hyun Ahn | 대구한의대학교 한방피부미용학과 ]
• 민유홍 [ Yu-Hong Min | 대구한의대학교 한방피부미용학과 ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  대한피부미용학회지 [Korean Journal of Aesthetics and Cosmetology]

• 간기

  격월간

• pISSN

  1738-4567

• 수록기간

  2003~2015

• 십진분류

  KDC 593 DDC 646