Earticle

초록

영어

Attention-deficit/hyperactivity disorder (ADHD) involves clinically het-erogeneous dysfunctions of sustained attention, with behavioral hyper-activity and impulsivity. The exact underlying mechanisms of ADHD are not known, however, impairment of dopaminergic system in the ni-grostriatal pathway was suggested as the one of the possible mecha-nisms of ADHD. Tyrosine hydroxylase (TH) is the rate-limiting enzyme that is involved in the synthesis of dopamine. Spontaneous hypertensive rats have been used as the animal model for ADHD. Physical exercise is known to restore the brain functions disrupted by several neurode-generative and psychiatric disorders. In the present study, we investi-gated whether treadmill exercise exerts therapeutic effect on ADHD. Social interaction test for the evaluation of impulsivity was performed using spontaneous hypertensive rats. TH expressions in the substantia nigra and striatum were evaluated by immunohistochemistry. In the present results, the rats of ADHD model showed hyper-social behav-iors. TH expressions in the substantia nigra and striatum were de-creased in the rats of ADHD model. Treadmill exercise alleviated hy-per-social behaviors in the ADHD rats. TH expressions of ADHD rats were also enhanced by treadmill exercise. Here in this study, we showed that treadmill exercise effectively alleviates the ADHD-induced symptoms through enhancing of TH expression in the brain.

목차

INTRODUCTION
 MATERIALS AND METHODS
  Animals and treatments
  Treadmill exercise protocol
  Social interaction test
  Tissue preparation
  TH immunhistochemistry
 Data analysis
 RESULTS
  Effect of treadmill exercise on social interaction in the ADHD-induced rats
  Effect of treadmill exercise on TH expression in the SN of the attention-deficit/hyperactivity disorder-induced rats
  Effect of treadmill exercise on TH-immunoreactive fiber density in the striatum of the ADHD-induced rats
 DISCUSSION
 REFERENCES

키워드

저자

• Dae-Jung Baek [ Department of Sport & Health Science, College of Natural Science, Sangmyung University, Seoul, Korea ]
• Chae-Bin Lee [ Department of Sport & Health Science, College of Natural Science, Sangmyung University, Seoul, Korea ]
• Seung-Soo Baek [ Department of Sport & Health Science, College of Natural Science, Sangmyung University, Seoul, Korea ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  JER [Journal of Exercise Rehabilitation]

• 간기

  격월간

• pISSN

  2288-176X

• eISSN

  2288-1778

• 수록기간

  2013~2026

• 등재여부

  SCOPUS,KCI 등재

• 십진분류

  KDC 517 DDC 613