Earticle

초록

영어

Attention-deficit/hyperactivity disorder (ADHD) patients show learning difficulty and impulsiveness. Exercise is known to improve learning abil-ity and memory function. In the present study, we investigated the dura-tion-dependence of the effect of treadmill exercise on spatial learning ability in relation with brain-derived neurotrophic factor (BDNF) expres-sion in ADHD rats. For this study, radial 8-arm maze test and western blot for BDNF and tyrosine kinase B (TrkB) were performed. Sponta-neous hypertensive rats were used as the ADHD rats and Wistar-Kyoto rats were used as the control rats. The rats in the exercise groups were forced to run on a treadmill for 10 min, 30 min, and 60 min once a day for 28 consecutive days. ADHD rats displayed impairment of spatial learn-ing ability, in contrast treadmill exercise ameliorated impairment of spa-tial learning ability. Treadmill exercise for 30 min per day showed most potent ameliorating effect on impairment of spatial learning ability. BDNF and TrkB expressions in the hippocampus were decreased in the ADHD rats, in contrast treadmill exercise enhanced BDNF and TrkB ex-pressions. Treadmill exercise for 30 min and for 60 min per day showed enhancing effects on BDNF and TrkB expressions. Treadmill exercise alleviated deficits in the spatial learning ability through enhancing BDNF and TrkB expressions in the ADHD rats. Treadmill exercise for 30 min per day can be considered as the most effective therapeutic mo-dality for the ADHD symptoms.

목차

Abstract
 INTRODUCTION
 MATERIALS AND METHODS
  Experimental animals and treatment
  Treadmill exercise protocol
  Radial 8-arm maze test
  Tissue preparation
  Western blot analysis for BDNF and TrkB expressions
  Data analysis
 RESULTS
  Effects of treadmill exercise on spatial learning ability in the radial 8-arm maze test
  Effects of treadmill exercise on BDNF and TrkB expressions in the hippocampus
 DISCUSSION
 CONFLICT OF INTEREST
 REFERENCES

키워드

저자

• Hye Im Jeong [ Department of Physical Education, Graduate School, Sungshin Women’s University, Seoul, Korea ]
• Eun-Sang Ji [ Dartment of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea ]
• Su-Hyun Kim [ Department of Physical Education, Graduate School, Dankook University, Seoul, Korea ]
• Tae-Wook Kim [ Department of Physical Education, College of Physical Education, Hanyang University, Seoul, Korea ]
• Sang-Bin Baek [ Department of Psychiatry, Gangneung Asan Hospital, Ulsan University, Gangneung, Korea ]
• Seung Wook Choi [ Department of Physical Education, Graduate School, Sungshin Women’s University, Seoul, Korea ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  JER [Journal of Exercise Rehabilitation]

• 간기

  격월간

• pISSN

  2288-176X

• eISSN

  2288-1778

• 수록기간

  2013~2026

• 등재여부

  SCOPUS,KCI 등재

• 십진분류

  KDC 517 DDC 613