Earticle

초록

영어

Alzheimer’s disease is the most common neurodegenerative disease and this disease induces progressive loss of memory function Scopol-amine is a non-selective muscarinic cholinergic receptor antagonist and it induces impairment of learning ability. Exercise is known to ame-liorate memory deficits induced by various brain diseases. In the pres-ent study, we investigated the effect of treadmill exercise on spatial learning ability in relation with cell proliferation in the hippocampus us-ing the scopolamine- induced amnesia mice. For the induction of amne-sia, 1 mg/kg scopolamine hydrobromide was administered intraperito-neally once a day for 14 days. Morris water maze test for spatial learning ability was conducted. Immonofluorescence for 5-bromo -2-deoxyuri-dine (BrdU) and western blot for brain-derived neurotrophic factor (BDNF) and its receptor tyrosine kinase B (TrkB) were performed. In the present results, scopolamine-induced amnesia mice showed deteriora-tion of spatial learning ability. Inhibition of cell proliferation and suppres-sion of BDNF and TrkB expressions were observed in the scopol-amine-induced amnesia mice. Treadmill exercise improved spatial learning ability and increased cell proliferation through activating of BD-NF-TrkB pathway in the amnesia mice. These findings offer a possibility that treadmill exercise may provide preventive or therapeutic value for the memory loss induced by variable neurodegenerative diseases in-cluding Alzheimer’s disease.

목차

Abstract
 INTRODUCTION
 MATERIALS AND METHODS
  Experimental animals
  Administration of scopolamine
  Treadmill exercise protocol
  Morris water-maze test
  Tissue preparation
  BrdU immunofluorescence
  Western blot analysis
  Data analysis
 RESULTS
  Effect of treadmill exercise on the time spent in the probe quadrant of Morris water maze test
  Effect of treadmill exercise on the number of BrdU-positive in the dentate gyrus of hippocampus
  Effect of treadmill exercise on BDNF and TrkB expressions in the hippocampus
 DISCUSSION
 CONFLICT OF INTEREST
 ACKNOWLEDGMENTS
 REFERENCES

키워드

저자

• Yu-Mi Heo [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea ]
• Mal-Soon Shin [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea ]
• Su-Hyun Kim [ Department of Physical Education, Graduate School, Dankook University, Seoul, Korea ]
• Tae-Wook Kim [ Department of Physical Education, College of Physical Education, Hanyang University, Seoul, Korea ]
• Sang-Bin Baek [ Department of Psychiatry, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, Korea ]
• Seung-Soo Baek [ Department of Sport & Health Science, College of Natural Science, Sangmyung University, Seoul, Korea ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  JER [Journal of Exercise Rehabilitation]

• 간기

  격월간

• pISSN

  2288-176X

• eISSN

  2288-1778

• 수록기간

  2013~2026

• 등재여부

  SCOPUS,KCI 등재

• 십진분류

  KDC 517 DDC 613