Earticle

초록

영어

Traumatic brain injury (TBI) is a leading cause of neurological deficit in the brain, which induces short- and long-term brain damage, cognitive impairment with/without structural alteration, motor deficits, emotional problems, and death both in children and adults. In the present study, we evaluated whether mild TBI in childhood causes persisting memory impairment until adulthood. Moreover, we investigated the influence of mild TBI on memory impairment in relation with hippocampal apoptosis. For this, step-down avoidance task, terminal deoxynucleotidyl transfer-ase-mediated dUTP nick end la¬beling (TUNEL) assay, and immunohis-tochemistry for caspase-3 were performed. Male Sprague-Dawley rats were used in the experiments. The animals were randomly divided into two groups: sham-operation group and TBI-induction group. The mild TBI model was created with an electromagnetic contusion device acti-vated at a velocity of 3.0 m/sec. The results showed that mild TBI during the pediatric stage significantly decreased memory retention. The num-bers of TUNEL-positive and caspase-3-positive cells were increased in the TBI-induction group compared to those in the sham-operation group. Defective memory retention and apoptosis sustained up to the adult stage. The present results shows that mild TBI induces long-last-ing cognitive impairment from pediatric to adult stages in rats through the high level of apoptosis. The finding of this study suggests that chil-dren with mild TBI may need intensive treatments for the reduction of long-lasting cognitive impairment by secondary neuronal damage.

목차

Abstract
 INTRODUCTION
 MATERIALS AND METHODS
  Animals and treatments
  Surgical procedure of mild TBI
  Step-down avoidance task
  Tissue preparation
  TUNEL staining
  Immunohistochemistry for caspase-3
  Statistical analysis
 RESULTS
  The effect of mild TBI during the pediatric stage on the short-term memory in the adult rats
  The effect of mild TBI during the pediatric stage on the number of TUNEL-positive cells in the hippocampus of adult rats
  The effect of mild TBI during the pediatric stage on caspase-3-positive cells in the hippocampus of adult rats
 DISCUSSION
 CONFLICT OF INTEREST
 ACKNOWLEDGMENTS
 REFERENCES

키워드

저자

• Mi-Sook Park [ Department of Health and Welfare for the Elderly, Graduate School, Daegu Haany University, Gyeongsan, Korea ]
• Hyean-Ae Oh [ Department of Health and Welfare for the Elderly, Graduate School, Daegu Haany University, Gyeongsan, Korea ]
• Il-Gyu Ko [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea ]
• Sung-Eun Kim [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea ]
• Sang-Hoon Kim [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea ]
• Chang-Ju Kim [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea ]
• Hyun-Bae Kim [ Department of Taekwondo, College of Physical Education, Kyung Hee University, Suwon, Korea ]
• Hong Kim [ Department of Oriental Sports Medicine, College of Biomedical Science, Daegu Haany University, Gyeongsan, Korea ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  JER [Journal of Exercise Rehabilitation]

• 간기

  격월간

• pISSN

  2288-176X

• eISSN

  2288-1778

• 수록기간

  2013~2026

• 등재여부

  SCOPUS,KCI 등재

• 십진분류

  KDC 517 DDC 613