Earticle

초록

영어

Intracerebral hemorrhage (ICH) is a major cause of death and disability in the elderly. In the present study, we examined the age-dependence of the effect of treadmill exercise on the intrastriatal hemorrhage-in-duced neuronal cell death in rats. Young (8 weeks old) and old (64 weeks old) Sprague-Dawley male rats were used in the present study. Intras-triatal hemorrhage was induced by injection of 0.2 U collagenase (1 μL volume) into the striatum using a stereotaxic instrument. The rats in the exercise groups were forced to run on a treadmill for 30 min daily for 7 days. Lesion size was determined by Nissl staining. Apoptosis was as-sessed by the terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay. In the present results, induction of hemorrhage increased lesion size and enhanced apoptosis. Treadmill exercise decreased the lesion size with suppressing apoptosis. Howev-er, the size of lesion induced by hemorrhage and the number of apop-totic cells were not different between young and old rats. Treadmill ex-ercise significantly reduced the ICH-induced lesion size and the number of apoptotic cells irrespective of age. The data suggest that treadmill exercise may provide therapeutic value against ICH by suppressing neu-ronal apoptosis regardless of age.

목차

Abstract
 INTRODUCTION
 MATERIALS AND METHODS
  Animals and treatments
  Induction of hemorrhage
  Treadmill exercise
  Tissue preparation
  Determination of lesion volume by Nissl staining
  Determination of DAN fragmentation by TUNEL staining
  Data analysis
 RESULTS
  Effect of treadmill exercise on the intrastriatal lesion volume
  The effect of treadmill exercise on the number of TUNEL-positive cells
 DISCUSSION
 CONFLICT OF INTEREST
 REFERENCES

키워드

저자

• Jin-Hwan Yoon [ Department of Sports Science, College of Life Science and Nano Technology, Hannam University, Daejeon, Korea ]
• Hee-Hyuk Lee [ Department of Sports Science, College of Life Science and Nano Technology, Hannam University, Daejeon, Korea ]
• Eun-Surk Yi [ Department of Exercise Rehabilitation & Welfare, College of Health Science, Gachon University, Incheon, Korea ]
• Soon Gi Baek [ Department of Sports Health Medicine, College of Health Science, Jungwon University, Chungcheongbuk-do, Korea ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  JER [Journal of Exercise Rehabilitation]

• 간기

  격월간

• pISSN

  2288-176X

• eISSN

  2288-1778

• 수록기간

  2013~2026

• 등재여부

  SCOPUS,KCI 등재

• 십진분류

  KDC 517 DDC 613