Earticle

초록

영어

The purpose of this study was to investigate the impact of the dura-tion-dependence of the one bout treadmill exercise on cell proliferation, stress, and central fatigue in rats. The animals were randomly divided into five groups: the non-exercise group, 1-h exercise group, 2-h exer-cise group, 4-h exercise group, and 6-h exercise group. The exercise load consisted of running at speed of 13 meters/min with the 0° inclina-tion. Cell proliferation in the hippocampal dentate gyrus was increased in response to one bout moderate treadmill exercise in all exercise groups. But there was no statistical significance between the exercise duration and cell proliferation. The optical density of glucocorticoid (GR)-positive cells in the hippocampal dentate gyrus was not changed by treadmill exercise at any exercise duration. Expressions of serotonin (5-hydroxytryptamine, 5-HT) and tryptophan hyroxylase (TPH) were in-creased by treadmill exercise only at 6 h duration. It seemed like that there was no additional benefits on cell proliferation over 2 h exercise due to stressful factors with over exercise dose, and there was no change of GR expression due to early assessment point of time. It can be sug-gested that the one-bout of moderate treadmill exercise increased cell proliferation, but treadmill exercise prolonged to 6 h induced central fa- tigue in rats.

목차

Abstract
 INTRODUCTION
 MATERIALS AND METHODS
  Animals and treatments
  Experimental design
  Tissue preparation
  BrdU immunohistochemistry
  Glucocorticoid receptors immunohistochemistry
  5-HT and TPH immunohistochemistry
  Data analysis
 RESULTS
  Cell proliferation in the hippocampal dentate gyrus
  Expression of GR in the hippocampal dentate gyrus
  Expressions of 5-HT and TPH in the dorsal raphe
 DISCUSSION
 CONFLICT OF INTEREST
 ACKNOWLEDGMENTS
 REFERENCES

키워드

저자

• Sang-Won Lee [ Department of Physical Education, Korea Military Academy, Seoul, Korea ]
• Yeon-Soo Kim [ Department of Physical Education, Seoul National University, Seoul, Korea ]
• Tae-Won Jun [ Department of Physical Education, Seoul National University, Seoul, Korea ]
• Jin-Hee Seo [ Division of Sports Science, Baekseok University, Cheonan, Korea ]
• Kijeong Kim [ School of Exercise and Sport Science, University of Ulsan, Ulsan, Korea ]
• Mal-Soon Shin [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea ]
• Chang-Ju Kim [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  JER [Journal of Exercise Rehabilitation]

• 간기

  격월간

• pISSN

  2288-176X

• eISSN

  2288-1778

• 수록기간

  2013~2026

• 등재여부

  SCOPUS,KCI 등재

• 십진분류

  KDC 517 DDC 613