Earticle

초록

영어

Perinatal hypoxic ischemia injury is a common cause of morbidity and mortality in neonates. Physical exercise may ameliorate neurological impairment by impeding neuronal loss following various brain insults. In the present study, the effect of treadmill exercise on sensory-motor function in relation with hippocampal apoptosis following hypoxic ischemia brain injury was investigated. Sensory-motor function was determined by walking initiation test and apoptosis was detected by terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) staining and caspase-3 immunohistochemistry. On postnatal 7 day, left common carotid artery of the neonatal rats was ligated for two hours and then the neonatal rats were exposed to hypoxia conditions for one hour. The rat pups in the exercise groups were forced to run on a motorized treadmill for 30 min once a day for 10 days, starting 22 days after induction of hypoxic ischemia brain injury. Hypoxic ischemia caused sensory-motor disturbance with enhancement of apoptosis in the hippocampus. Short-term treadmill exercise suppressed hypoxic ischemia injury-induced apoptosis in the hippocampus, and preserved sensory-motor function of hypoxic ischemia injury rat pups.

목차

Abstract
 INTRODUCTION
 MATERNAL AND METHODS
  Animals and treatments
  Induction of hypoxic ischemia brain injury
  Treadmill exercise protocol
  Walking initiation test
  Tissue preparation
  TUNEL staining
  Caspase-3 immunohistochemistry
  Data analyses
 RESULTS
  Effect of short-term treadmill exercise on sensorimotor function in the 20 cm and 60 cm walking initiation test
  Effect of short-term treadmill exercise on the DNA fragmentation in the hippocampal dentate gyrus
  Effect of short-term treadmill exercise on the caspase-3 expression in the hippocampal dentate gyrus
  DISCUSSION
  CONFLICT OF INTEREST
  REFERENCES

키워드

저자

• Jun-Ho Choi [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea ]
• Tae-Soo Kim [ Division of Exercise and Health Science, College of Art and Physical Education, Incheon National University, Incheon, Korea ]
• Joon-Ki Park [ Division of Exercise and Health Science, College of Art and Physical Education, Incheon National University, Incheon, Korea ]
• Young-Je Sim [ Department of Physical Education, College of Natural Sciences, Kunsan National University, Gunsan, Korea ]
• Kijeong Kim [ School of Exercise and Sport Science, University of Ulsan, Ulsan, Korea ]
• Sam-Jun Lee [ Department of Physical Education, College of Health, Social Welfare and Education, Tong Myong University, Busan, Korea ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  JER [Journal of Exercise Rehabilitation]

• 간기

  격월간

• pISSN

  2288-176X

• eISSN

  2288-1778

• 수록기간

  2013~2026

• 등재여부

  SCOPUS,KCI 등재

• 십진분류

  KDC 517 DDC 613