Earticle

초록

영어

In this work, the extract of Scutellaria baicalensis and its key flavonoids such as baicalin, baicalein and wogonin were studied to characterize as a cosmetic ingredient. The MMP-1 production in UV irradiated human dermal fibroblast was tested using Scutellaria baicalensis extract and its flavonoids and it was found that the production of MMP-1 was inhibited at low concentration but reversed this phenomena at high concentration of extract or flavonoids. That went the same with experiments with and without UV. How baicalein and wogonin would influence kinase activity was examined, and the results showed that both the extracts are vulnerable to kinase while they are related to JNK activation. Considering what has been learned above, kinase activity was affected by different concentration of extract, and that should be taken into consideration when the Scutellaria baicalensis extract is used to make functional cosmetics in the future.

목차

Abstract
 Ⅰ. 서론
 Ⅱ. 실험재료 및 방법
  1. 세포배양
  2. 황금 열수 추출물 제조
  3. 사용기기
 Ⅲ. 연구결과 및 고찰
  1. 황금 추출물의 HPLC 결과
  2. 황금 추출물의 세포독성
  3. 황금 추출물의 MMP-1 발현 변화 측정
  4. 황금 주요 플라보노이드 MMP-1 발현 변화 측정
  5. 황금의 주요 플라보노이드 고농도 첨가가 MMP-1 발현에미치는 영향
  6. 황금 주요 플라보노이드 Baicalein이 MAPK 활성에 미치는영향
  7. 황금 주요 플라보노이드 Wogonin이 MAPK 활성에 미치는영향
  8. Baicalein과 Wogonin이 kinase 활성화에 미치는 영향
 Ⅳ. 결론
 참고문헌

키워드

저자

• 김나영 [ Na-young Kim | 건국대학교 생물공학과 ]
• 문지선 [ Ji-seon Moon | 건국대학교 생물공학과 ]
• 최태부 [ Tae-boo Choe | 건국대학교 생물공학과 ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  대한피부미용학회지 [Korean Journal of Aesthetics and Cosmetology]

• 간기

  격월간

• pISSN

  1738-4567

• 수록기간

  2003~2015

• 십진분류

  KDC 593 DDC 646