Earticle

초록

영어

Progressive loss of dopaminergic neurons in substantia nigra is a key pathogenesis of Parkinson’s disease. In the present study, we investi-gated the effects of treadmill exercise on short-term memory, apoptotic dopaminergic neuronal cell death and fiber loss in the nigrostriatum, and cell proliferation in the hippocampal dentate gyrus of Parkinson’s rats. Parkinson’s rats were made by injection of 6- hydroxydopamine (6-OHDA) into the striatum using stereotaxic instrument. Four weeks after 6-OHDA injection, the rats in the 6- OHDA-injection group exhibited significant rotational asymmetry following apomorphine challenge. The rats in the exercise groups were put on the treadmill to run for 30 min once a day for 14 consecutive days starting 4 weeks after 6-OHDA injection. In the present results, extensive degeneration of the dopaminergic neurons in the substantia nigra with loss of dopaminergic fibers in the striatum were produced in the rats without treadmill running, which resulted in short-term memory impairment. However, the rats performing treadmill run-ning for 2 weeks alleviated nigrostriatal dopaminergic cell loss and alle-viated short-term memory impairment with increasing cell proliferation in the hippocampal dentate gyrus of Parkinson’s rats. The present re-sults show that treadmill exercise may provide therapeutic value for the Parkinson’s disease.

목차

Abstract
 INTRODUCTION
 MATERIALS AND METHODS
  Animals and treatments
  Apomorphine-induced rotation test
  Exercise protocol
  Step-down avoidance task
  Tissue preparation
  TH immunohistochemistry
  Caspase-3 immunohistochemistry
  BrdU immunohistochemistry
  Data analysis
 RESULTS
  Effect of 6-OHDA treatment on apomorphine-induced rotation test
  Effect of treadmill exercise on latency in the step-down avoidance task after 6-OHDA-injection
  Effect of treadmill exercise on TH expression in the nigrostriatum after 6-OHDA injection
  Effect of treadmill exercise on caspase-3 expression in the substantia nigra after 6-OHDA injection
  Effect of treadmill exercise on cell proliferation in the dentate gyrus after 6-OHDA injection
 DISCUSSION
 CONFLICT OF INTEREST
 REFERENCES

키워드

저자

• Han-Sam Cho [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea, Department of Physical Education, College of Education, Seoul National University, Seoul, Korea ]
• Mal-Soon Shin [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea ]
• Wook Song [ Department of Physical Education, College of Education, Seoul National University, Seoul, Korea ]
• Tae-Won Jun [ Department of Physical Education, College of Education, Seoul National University, Seoul, Korea ]
• Baek-Vin Lim [ Department of Exercise Prescription, Division of Leisure & Sports Science, Dongseo University, Busan, Korea ]
• Young-Pyo Kim [ Faculty of Exercise and Sports Sciences, College of Natural Sciences, Jeju National University, Jeju, Korea ]
• Chang-Ju Kim [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  JER [Journal of Exercise Rehabilitation]

• 간기

  격월간

• pISSN

  2288-176X

• eISSN

  2288-1778

• 수록기간

  2013~2026

• 등재여부

  SCOPUS,KCI 등재

• 십진분류

  KDC 517 DDC 613