Earticle

초록

영어

In the present study, we investigated the effect of swimming training and sudden detraining on learning ability and spatial memory capability and on neurogenesis and brain-derived neurotrophic factor (BDNF) expression in the hippocampus of mice. Male ICR mice were randomly assigned into three groups (n= 15 in each group): the control group, the swimming training group, and the detraining group. The mice in the swimming training group were made to swim (6 days/week, 60 min/day) for 8 weeks. The mice in the detraining group were accomplished the same swimming program for 4 weeks and then discontinued exercise for 4 weeks. In the present results, enhanced short-term and spatial learning memories and increased hippocampal neurogenesis and BDNF expression were observed in the mice of the swimming training group. In contrast, decreased short-term and spatial learning memories were observed in the mice of the swimming detraining group compared to the control level. Hippocampal neurogenesis and BDNF expression were also decreased in the mice of the detraining group near to the control level. Here in this study, we suggest that sudden cessation of exercise training might bring decline of the brain functions.

목차

Abstract
 INTRODUCTION
 MATERIALS AND METHODS
  Animals and treatments
  Swimming training and detraining
  Step-down avoidance test
  Radial-arm maze test
  Tissue preparation
  Immunohistochemistry
  Western blot analysis
  Statistical analysis
 RESULTS
  Effect of training and detraining on step-down avoidance test
  Effect of training and detraining on radial-arm maze test
  Effect of training and detraining on the hippocampal neurogenesis
  Effect of training and detraining on the BDNF protein expression
 DISCUSSION
 CONFLICT OF INTEREST
 ACKNOWLEDGMENTS
 REFERENCES

키워드

저자

• You-Mi Kim [ Department of Sports Science, College of Life Science and Nano Technology, Hannam University, Daejeon, Korea ]
• Eun-Sang Ji [ Department of Sport & Health Science, College of Natural Science, Sangmyung University, Seoul, Korea ]
• Sung-Jin Yoon [ Department of Physical Education, College of Education, Korea University, Seoul, Korea ]
• Jin-Hwan Yoon [ Department of Sports Science, College of Life Science and Nano Technology, Hannam University, Daejeon, Korea ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  JER [Journal of Exercise Rehabilitation]

• 간기

  격월간

• pISSN

  2288-176X

• eISSN

  2288-1778

• 수록기간

  2013~2026

• 등재여부

  SCOPUS,KCI 등재

• 십진분류

  KDC 517 DDC 613