Earticle

초록

영어

Maternal isolation has been used as a valid animal model of early life stress, and it induces depression to offspring. Exercise ameliorates the incidence and severity of stress-related mood disorders, such as depression and anxiety. Here in this study, we investigated the effects of treadmill exercise on brain neuronal excitation in the rat pups with maternal isolation-induced depression. Forced swimming test and immunohistochemistry for glucocorticoid receptor and c-Fos in the hippocampal dentate gyrus and hypothalamic paraventricular nucleus were conducted. Maternal isolation lasted for 6 hours per day and was continued from postnatal day 1 to postnatal day 30. The rat pups in the exercise group were forced to run on a treadmill for 30 min once a day for 10 consecutive days, starting from the postnatal day 21 until the postnatal day 30. In the present results, treadmill exercise alleviated depressive state in the maternal separated rat pups, as potently as fluoxetine treatment. Treadmill exercise also restored the expressions of glucocorticoid receptor and c-Fos in the hippocampal dentate gyrus and hypothalamic paraventricular nucleus of the maternal separated rat pups near to the control level, as fluoxetine treatment. The present study suggests the possibility that treadmill exercise can be used as the therapeutic strategy for the childhood depression induced by disturbed motherchild relationship.

목차

Abstract
 INTRODUCTION
 MATERIALS AND METHODS
  Animals and treatments
  Maternal isolation
  Treadmill exercise protocol and fluoxetine administration
  Forced swimming test
  Tissue preparation
  GR immunohistochemistry
  c-Fos immunohistochemistry
  Data analyses
 RESULTS
  Effect of treadmill exercise on the depressive state in the forced swimming test
  Effect of treadmill exercise on the expression of GR in the hippocampal dentate gyrus
  Effect of treadmill exercise on the c-Fos expression in the hippocampal dentate gyrus
  Effect of treadmill exercise on the GR expression in the hypothalamic paraventricular nucleus
  Effect of treadmill exercise on the c-Fos expression in the hypothalamic paraventricular nucleus
 DISCUSSION
 CONFLICT OF INTEREST
 ACKNOWLEDGMENTS
 REFERENCES

키워드

저자

• Joon-Ki Park [ Division of Exercise and Health Science, Incheon National University, Incheon, Korea ] Corresponding author
• Sam-Jun Lee [ Department of Physical Education, College of Health, Social Welfare and Education, Tong Myong University, Busan, Korea ]
• Chang-Suk Oh [ Department of exercise prescription, Baeksuk University, Chungnam, Korea ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  JER [Journal of Exercise Rehabilitation]

• 간기

  격월간

• pISSN

  2288-176X

• eISSN

  2288-1778

• 수록기간

  2013~2026

• 등재여부

  SCOPUS,KCI 등재

• 십진분류

  KDC 517 DDC 613