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Suppressive effects of 70% ethanolic Auricularia auricula-judae extract in adipogenesis and lipogenesis on 3T3-L1 preadipocytes

첫 페이지 보기
  • 발행기관
    한국버섯학회 바로가기
  • 간행물
    버섯 바로가기
  • 통권
    제15권 2호 통권 24호 (2011.11)바로가기
  • 페이지
    pp.61-61
  • 저자
    Md. Ahsanur Reza, Joong-su Lee, Seung-jin Lee, Woo-Sik Jo, Seung-chun Park
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A193844

원문정보

초록

영어
The aim of this study was to investigate the suppressive activity of 70% ethanol extract and its dichloromethane fraction from Auricularia auricula-judae against adipogenesis and lipogenesis in 3T3-L1 preadipocytes. The ethanol extract and its dichloromethane fraction suppressed the differentiation and decreased lipid droplets in vitro. The dose-dependent increasing concentration of glycerol and lower triglycerides accumulation were found significantly (P < 0.05) with the treatment of both fractions from 70% ethanolic Auricularia auricula-judae extract and the glycerol-3-3phosphate dehydrogenase (GPDH) activity was also inhibited by both extracts. Further, the expression of adipogenic mRNAs were investigated by RT-PCR amplification. The key transcriptional factors, PPARγ and C/EBPα were decreased significantly at dose-dependent manner by both extracts of Auricularia auricula-judae. The expressions of LPL and FAS were also decreased by presence of these extracts. The decreased expressions of C/EBPβ, C/EBPγ and ACC1 were observed only by ethanol extract at 300 μg/ml concentration, while the expression of SREBP-1c, GLUT4 and aP2 were not altered in the 3T3-L1 adipocytes. These changes were occurred without the cytotoxic effect of both extracts against 3T3-L1 adipocytes in vitro. A positive control, fenofibrate inhibited the differentiation, triglycerides accumulation through PPARγ signaling by 2/3 reduction of PPARγ expression. Thus, these findings suggest that both extracts of Auricularia auricula-judae might be used to inhibit the differentiation of 3T3-L1 preadipocytes and reduction of triglycerides accumulation.

저자

  • Md. Ahsanur Reza [ College of Veterinary Medicine, Kyungpook National University, Daegu 702-701, Republic of Korea ]
  • Joong-su Lee [ College of Veterinary Medicine, Kyungpook National University, Daegu 702-701, Republic of Korea ]
  • Seung-jin Lee [ College of Veterinary Medicine, Kyungpook National University, Daegu 702-701, Republic of Korea ]
  • Woo-Sik Jo [ Department of Agricultural Environment, Gyeongbuk Agricultural Technology Administration, Daegu 702-701, Republic of Korea ]
  • Seung-chun Park [ College of Veterinary Medicine, Kyungpook National University, Daegu 702-701, Republic of Korea ] Corresponding author

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    한국버섯학회 [The Korean Society of Mushroom Science]
  • 설립연도
    1997
  • 분야
    농수해양>농학
  • 소개
    우리나라의 버섯 연구와 관련 산업의 발전에 기여하고 버섯관련 연구자와 관련산업 종사자간의 학술정보 등의 교류를 목적으로 한다.

간행물

  • 간행물명
    버섯 [Mushroom]
  • 간기
    반년간
  • 수록기간
    1997~2025
  • 십진분류
    KDC 525 DDC 635

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