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Antitumor activity of dichloromethane fraction separated from Auricularia auricula-judae 70% ethanol extracts against human bronchioalveolar and gastric tumor cells

첫 페이지 보기
  • 발행기관
    한국버섯학회 바로가기
  • 간행물
    버섯 바로가기
  • 통권
    제15권 2호 통권 24호 (2011.11)바로가기
  • 페이지
    pp.60-61
  • 저자
    Md. Ahsanur Reza, Joong-su Lee, Seung-jin Lee, Woo-Sik Jo, Seung-chun Park
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A193841

원문정보

초록

영어
The aim of this study was to investigate the antitumor activity of solvent fractions from Auricularia auricula-judae 70% ethanol extract and confirmed the active components of dichloromethane fraction showing a potent antitumor activity than other fractions in the broncheoalveolar and gastric cancer cells. The solvent fractions of Auricularia auricula-judae extract, inhibited the growth proliferation of tumor cells in dose-dependent manner. The principle components of dichloromethane fraction were 5,11,17,23-tetrakis (1,1-dimethyl)-28-methoxypentacyclo [19.3.1.1 (3,7).1 (… (65.85%) and diazane (6.17%).
The antitumor active components, diazane and gibberellic acid (GA3) were identified in this fraction by GC-MS analysis and lower antitumor activities than dichloromethane fraction. The unknown components of dichloromethane fraction were responsible for its cytotoxic effects on tumor cells. Based on IC50 value, gibberellic acid was little cytotoxic itself. According to PCR amplification, the apoptosis of tumor cells were induced by the down-regulation of Bcl-2 and over-expression of P53 on the presence of solvent fractions, diazane and gibberellic acid. Thus, these findings suggest that the dichloromethane might be used as functional feed additive that suppress the tumor growth in the body than other solvent fractions of Auricularia auricula-judae extracts.

저자

  • Md. Ahsanur Reza [ College of Veterinary Medicine, Kyungpook National University, Daegu 702-701, Republic of Korea ]
  • Joong-su Lee [ College of Veterinary Medicine, Kyungpook National University, Daegu 702-701, Republic of Korea ]
  • Seung-jin Lee [ College of Veterinary Medicine, Kyungpook National University, Daegu 702-701, Republic of Korea ]
  • Woo-Sik Jo [ Department of Agricultural Environment, Gyeongbuk Agricultural Technology Administration, Daegu 702-701, Republic of Korea ]
  • Seung-chun Park [ College of Veterinary Medicine, Kyungpook National University, Daegu 702-701, Republic of Korea ] Corresponding author

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    한국버섯학회 [The Korean Society of Mushroom Science]
  • 설립연도
    1997
  • 분야
    농수해양>농학
  • 소개
    우리나라의 버섯 연구와 관련 산업의 발전에 기여하고 버섯관련 연구자와 관련산업 종사자간의 학술정보 등의 교류를 목적으로 한다.

간행물

  • 간행물명
    버섯 [Mushroom]
  • 간기
    반년간
  • 수록기간
    1997~2025
  • 십진분류
    KDC 525 DDC 635

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