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Induction of apoptosis by cordycepin via ROS generation in human leukemia cells

첫 페이지 보기
  • 발행기관
    한국버섯학회 바로가기
  • 간행물
    한국버섯학회지 바로가기
  • 통권
    제7권 제2호 (2009.06)바로가기
  • 페이지
    pp.65-65
  • 저자
    Jin-Woo Jeong, Cheol Park, Cheng-Yun Jin, Yung-Hyun Choi, Jae-Dong Lee
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A193714

원문정보

초록

영어
Cordycepin (3’-deoxyadenosine) is a polyadenylation specific inhibitor, one of the components of Cordyceps militaris. It has been shown to possess many pharmacological activities including immunologically stimulating, anti-tumor, anti-virus, and anti-infection effects. However, its molecular mechanisms are poorly understood. In this study, the apoptotic effects by cordycepin were investigated in human leukemia cells. Cordycepin treatment inhibited leukemia cells growth a concentration-dependent manner by inducing apoptosis,as evidenced by morphological change and apoptotic cell death such as formation of apoptotic bodies, DNA fragmentation and increased populations of apoptoticsub G1 phase. Induction of apoptosis by cordycepin in leukemia cells were associated with modulation of Bcl-2 member and inhibitor of apoptosis (IAP) proteins expression. Cordycepin also increased ROS generation, activation of caspase-3, caspase-8, caspase-9, cleavage of poly(ADP-ribose) polymerase (PARP), -catenin and phospholipase (PLC)-1 protein. Both the this effect by cordycepin treatment were significantly inhibited by NAC, a ROS scavenger, demonstrating the important role of ROS in the observed cytotoxic effect. This results suggested that cordycepin may be a potential chemotherapeutic agent for the treatment of leukemia patients.

저자

  • Jin-Woo Jeong [ Department of Microbiology, College of Natural Sciences, Pusan National University, Busan 609-735, Korea. ]
  • Cheol Park [ Blue-Bio Industry RIC, Depts. ]
  • Cheng-Yun Jin [ Department of Biochemistry, Dongeui University College of Oriental Medicine and Department of Biomaterial Control (BK21 program), Dongeui University Graduate School, Busan 614-052, Korea. ]
  • Yung-Hyun Choi [ Department of Biochemistry, Dongeui University College of Oriental Medicine and Department of Biomaterial Control (BK21 program), Dongeui University Graduate School, Busan 614-052, Korea. ]
  • Jae-Dong Lee [ Department of Microbiology, College of Natural Sciences, Pusan National University, Busan 609-735, Korea. ] Corrresponding author

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    한국버섯학회 [The Korean Society of Mushroom Science]
  • 설립연도
    1997
  • 분야
    농수해양>농학
  • 소개
    우리나라의 버섯 연구와 관련 산업의 발전에 기여하고 버섯관련 연구자와 관련산업 종사자간의 학술정보 등의 교류를 목적으로 한다.

간행물

  • 간행물명
    한국버섯학회지 [Journal of MUSHROOMS]
  • 간기
    계간
  • pISSN
    1738-0294
  • eISSN
    2288-8853
  • 수록기간
    2003~2025
  • 등재여부
    KCI 등재
  • 십진분류
    KDC 525 DDC 635

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