Earticle

초록

영어

The purpose of this study is to investigate the influence of black ginseng (BG) on induced IL-6, IL-8 and MCP- 1 secretion by house dust mite in THP-1 (human acute monocytic leukemia cell line) and EoL-1 (human eosinophilic leukemic cells) cell lines. The house dust mite (Dermatophagoides pteronissinus, D. pteronissinus ) plays a key role in the pathogenesis of allergic diseases, including atopic dermatitis and asthma. Monocyte chemoattractant protein 1 (MCP-1), interleukin-6 (IL-6) and interleukin-8 (IL-8) play a pivotal role in mediating the infiltration of various cells into the skin of atopic dermatitis. The korean ginseng (radix and leaf) was steamed to 3 hr at 120℃ under high pressure. The contents of benzopyrene which was known as a tumor promoting agent were analysed. Also, the inhibitory effect of BG on the induced IL-6, IL-8 and MCP-1 secretion by D. pteronissinus extract (DpE) in THP-1 and MCP-1 cells was examined. The BG extract (radix and leaf) potently suppressed the elevated production of IL-6 and IL-8 induced by DpE treatment in THP-1 and EoL-1 cells. Among them, the crude saponin fraction of BG leaf exhibited the most potent inhibitory activity. Based on the present results, it can be suggested that the 3 hr steaming at 120℃ under high pressure is the most optimal processing condition and BG may be useful to develop functional food on atopic dermatitis.

목차

Abstract
 Ⅰ. 서론
 Ⅱ. 연구방법
  1. 연구재료
  2. 흑삼의 벤조피렌 함량 측정
  3. 아토피피부염의 억제활성 측정
  4. 통계처리
 Ⅲ. 연구결과 및 고찰
  1. 흑삼에 존재하는 벤조피렌 함량
  2. THP-1세포에서 집 먼지 진드기로 유발한 IL-6, IL-8 및 MCP-1에 대한 흑삼 추출물의 억제활성
  3. EoL-1세포에서 집 먼지 진드기로 유발한 IL-6, IL-8 및 MCP-1에 대한 흑삼 추출물의 억제활성
 Ⅳ. 결론
 참고문헌

키워드

저자

• 신영진 [ Young Jin Shin | 충남대학교 약학과 ]
• 장현희 [ Hyun Hee Jang | 경복대학교 미용예술학부 ]
• 송규용 [ Gyu Yong Song | 충남대학교 약학과 ] Corresponding Author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  대한피부미용학회지 [Korean Journal of Aesthetics and Cosmetology]

• 간기

  격월간

• pISSN

  1738-4567

• 수록기간

  2003~2015

• 십진분류

  KDC 593 DDC 646