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Effects of exercise on the c-Fos expression in locus coeruleus in the streptozotocin-induced sporadic Alzheimer's disease rats

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  • 발행기관
    한국운동재활학회 바로가기
  • 간행물
    한국운동재활학회지 바로가기
  • 통권
    제6권 제4호 통권14호 (2010.11)바로가기
  • 페이지
    pp.159-167
  • 저자
    Young-Duck Lee, Sam-Jun Lee
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A131929

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원문정보

초록

영어
In the present study, the effect of treadmill exercise was investigated on intracerebroventricular injection of streptozotocin (ICV STZ)-induced c-Fos expression in rats. We resulted in accelerated the c-Fos expression from locus coeruleus (LC) for sporadic Alzheimer's disease (SAD) rat models. It was revealed that a protective mechanism enhanced the c-Fos positive cells for LC with the SAD and exercise group in ICV STZ model of sporadic dementia of Alzheimer's disease type in rats. Adult male Sprague-Dawley rats were injected with ICV STZ bilaterally, on 1 times/day for three day. The neuronal activity was assessed using the immunohistochemistry. The rats were divided with three groups(the sham-operation group; the ICV STZ-injected group; the ICV STZ-injected and exercise group). Rats were motivated to run with gentle hand prodding. Electrical shock was avoided as a negative reinforcement because this would add undue stress not typically associated with volitional exercise. Exercise was performed on a motorized treadmill adapted with lanes for the rats to run in individualized compartments at the seven days after the surgery. Rats were exercised for 7 days at 8 m/min for the 5 min and then 12 m/min at 5% grade for the 25 min, which corresponded to 70% of their VO2max. In conclusion, the present study was investigated that treadmill exercise accelerated the expression of c-Fos positive cells in LC from the SAD-induced rats. Over-expression in c-Fos positive cells through exercise may therefore be reversed by treadmill exercise following SAD-induced suppression of c-Fos expression. Further examination of the involvement of noradrenaline level in exercise-induced neuroprotection will aid in the amelioration of SAD severity for the prevention and treatment of neurodegenerative insults

목차

ABSTRACT
 Introduction
  1. Purpose and Need
 Materials and Methods
  1. Animals
  2. Intracerebroventricular injection of STZ
  3. Exercise Protocol
  4. Tissue Preparation
  5. c-Fos immunohistochemistry in the LC
  6. Statistical Analysis
 Results
  1. The number of c-Fos positive cells in the LCregions
 Discussion
 Conclusion
 References

키워드

Treadmill Exercise c-Fos Alzheimer’s disease Locus coeruleus

저자

  • Young-Duck Lee [ Tong Myung Univ. ]
  • Sam-Jun Lee [ Tong Myung Univ. ]

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    한국운동재활학회 [Korean Society of Exercise Rehabilitation]
  • 설립연도
    2004
  • 분야
    의약학>재활의학
  • 소개
    한국운동재활학회는 사회적, 정신적, 신체적 통합건강복지 이론의 학술연구와 회원 상호간 학술교류 증진을 장려함으로써 학문적 발전을 도모하고 나아가 건강복지선진국 발전에 이바지함을 목적으로 한다.

간행물

  • 간행물명
    한국운동재활학회지 [Korean Journal of Exercise Rehabilitation]
  • 간기
    계간
  • pISSN
    1976-6319
  • 수록기간
    2005~2013
  • 십진분류
    KDC 517 DDC 613

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