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1

양돈농가의 경영리스크 평가에 관한 연구

최문식, 이소진, 장현욱

한국경영컨설팅학회 경영컨설팅연구 제17권 제1호 통권 제52호 2017.02 pp.231-239

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양돈농가의 경영활동은 다양한 불확실한 환경요인에 노출되어 그 불안정성이 가속화 되고 있다. 양돈농가들은 스스로 효과적인 대응을 하지 못하고 있으며, 사후적 지원만 기대하고 있는 실정이다. 양돈경영에서 리스크 관리는 그 중요성은 충분히 인식되고 있지만, 아직까지 주요 요인별 리스크에 대한 체계적인 분석과 대처가 이루어지지 않고 있다. 농업소득 안정화를 위해서는 경영활동에서 발생될 수 있는 불확실한 리스크를 사전에 인식하고 평가하여 체계적으로 대응수단을 작동시켜 손실을 회피하거나 손실규모를 완화해야 한다. 정량적이고 체계적인 리스크 요인의 분석과 심각성 평가를 통해 주요 리스크의 재식별과 이에 대한 중점관리가 필요하다. ​본 연구에서는 양돈경영 전반에 내포된 리스크 요인들을 규명하여 체크리스트를 제시하고, 축산전문가와 양돈농가를 대상으로 한 설문분석을 통해 각 항목의 정량화된 중요도를 도출하였다. 또한 항목별 가중치를 고려하여 위험도를 분석함으로써 양돈경영 리스크 요인의 위험순위 및 위험등급을 평가하였다.
Management of hog-raising farms is exposed to a variety of uncertain environmental factors that it is becoming increasingly insecure. Hog-raising farms are not able to take effective action on their own and are just waiting for the support from the government. Despite the awareness of the importance of risk management of hog-raising farm, people have yet to perform systematic analysis for major risk factors. Any uncertain risk that can arise in the management activities must be recognized and assessed for the stabilization of agricultural income and systematic response should be taken to avoid or mitigate any damage or loss. Quantitative and systematic analysis of risk factors is needed for the re-identification and focused management of major risks. In the present paper, the level of importance of each category was derived from the survey conducted on hog-raising farms and experts. In addition, the weight factor was considered for each category for risk analysis, in order to assess risk level and risk rating of the risk factors in hog-raising farms.

4,000원

2

울산 지역 소아청소년과 및 이비인후과에서의 항염증제 처방 형태 분석

김성철, 김영록, 황재윤, 장현욱, 남두현

한국임상약학회 한국임상약학회지 제20권 제3호 2010.12 pp.205-212

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The prescription sheets for outpatients from July 2008 to June 2009 from 7 community pharmacies in Ulsan City were surveyed for the anti-inflammatory drug (AID) prescription pattern. The AID prescription rate of pediatricians and ENT physicians were 30.0% and 34.8%, respectively. The oral steroidal anti-inflammatory drugs (SAIDs) were prescribed as much as 3.9% by pediatricians and 10.3% by ENT physicians. The chiefly prescribed oral SAID was prednisolone in pediatric clinics and methylprednisolone in ENT clinics. Meanwhile the prescription rate of oral non-steroidal antiinflammatory drug (NSAID) was 22.5% by pediatricians and 21.4% in ENT physicians. The most favorable NSAIDs were propionate derivatives in both clinics. In case of externally-applied SAIDs, the prescription rate of pediatricians was 3.6% and that of ENT physicians was 2.8%. Among them, nasal spray, inhalant and gargle formulations for upper respiratory infection (URI) treatment occupied 35.8% of externally-applied SAIDs in pediatric linics and 59.7% in ENT clinics. Further, it was observed that ENT physicians favored much stronger SAIDs in Group III of ATC classification (75.4% of externally-applied SAIDs) than pediatricians (49.2%). In the survey of AID combination rate, pediatric clinics showed much lower rate (1.4% of total AID prescriptions) than ENT clinics (7.5%). Among them, the combination rate of oral SAID and oral NSAID by ENT physicians (52.2% of total AID combinations) was much higher than pediatricians (36.6%), which might be over-prescription of AID agents. In conclusion, the AID prescription rate as well as AID combination rate, especially in SAID prescriptions, was much higher in ENT than pediatric clinics, which implies the higher confidency on AID drugs of ENT physicians even though the severity of patient's symptom could be considered.

4,000원

3

송기 분말이 Loperamide로 유도된 흰쥐의 변비 완화에 미치는 효과

이창현, 장현욱, 김영, 이영은

[Kisti 연계] 동아시아식생활학회 동아시아식생활학회지 Vol.27 No.5 2017 pp.548-557

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This study investigated the effects of insoluble dietary fibers from pine (Pinus radiata D. Don) inner bark powder (PIBP) on loperamide constipation in rats. Male Sprague-Dawley rats were administered PIBP in their diets at concentrations of 5% and 10% for 4 weeks. Rats were divided in to four groups, normal diet group (Cont), a normal diet and loperamide group (Lop), 5% PIBP experimental diet and loperamide group (Lop+PIBP 5%), and 10% PIBP experimental diet and loperamide group (Lop+PIBP 10%). Constipation was induced by oral administration of loperamide (2 mg/kg, twice per day) for the last three days of the experiment. Food intake, body weight, properties of feces, gastrointestinal transit time, and serum lipid profiles were measured. When compared with the normal diet and loperamide group (Lop), there were increases in fecal pellet number (p<0.05), wet weight (p<0.001), and water content (p<0.001). Positive results were derived from relevant indicators to improve constipation. In addition, the number of fecal pellets in the colon was not significant, and decreased as PIBP content increased. PIBP had a concentration-dependent effect on reduction of total cholesterol, LDL-cholesterol, and triglycerides and elevation of HDL-cholesterol. These results indicate that PIBP may effectively prevent constipation.

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4

알로에 분말을 첨가한 생면의 제조조건 최적화

장현욱, 이보영, 김은숙, 이영은

[Kisti 연계] 한국식품조리과학회 한국식품조리과학회지 Vol.32 No.6 2016 pp.704-715

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Purpose: This study was conducted to optimize the conditions of manufacturing the wet noodle added with Aloe powder. Methods: The I-optimal design of response surface methodology (RSM) was used for the optimization of added amount of Aloe powder, water content, and kneading time as the independent variables. The quality characteristics (color, texture, water absorption ratio, volume, turbidity) and sensory characteristics (color, flavor, taste, mouth feel, overall acceptance) were analyzed as dependent variables. Results: The lightness, redness, and yellowness of the Aloe noodle were all lowered with the addition of Aloe powder. All texture characteristics such as hardness, elasticity and chewiness of Aloe noodle showed the tendency to increase with increasing amount of Aloe added and kneading time. The water uptake and the volume expansion tended to increase with increasing aloe addition and water addition. As the kneading time increased, the dissolution of solids decreased and the turbidity tended to decrease. Aloe powder content influenced the color, flavor and taste of the noodles most among independent variables, and the mouthfeel of the noodle influenced by the water addition and the kneading time. Conclusion: Aloe noodle showed the best desirability with 3.03% of Aloe powder, 43.56% of water content and 13.06 min of kneading time by RSM analysis. Aloe noodles prepared under these optimized conditions are expected to be able to manufacture and utilize functional Aloe noodles by meeting the content of isobarbaloin, which helps the intestinal functional activity.

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5

불가사리 부타놀 분획의 항알러지 활성

양주혜, 나민균, 장현욱

[Kisti 연계] 대한약학회 약학회지 Vol.55 No.4 2011 pp.295-300

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We investigated the effects of butanol fraction of Asterias amurensis (BFA) on the anti-allergic activity. BFA inhibited both cyclooxygenase-2 dependent prostaglandin $D_2$ and 5-lipoxygenase dependent leukotriene $C_4$ generation in a concentration-dependent manner with $IC_{50}$ values of 174.6 and 22.2 ${\mu}g$/ml, respectively. In addition, BFA also inhibited the degranulation in a dose dependent manner. Furthermore, oral administration of BFA inhibited IgE-mediated passive cutaneous anaphylaxis in mice. These results suggested that BFA may be useful in regulating mast cell-mediated allergic diseases.

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6

새로운 계열의 선택적 COX-2 저해제: Luotonin A 동족체 및 그 질소 유도체

김동현, 량경록, 오준석, 장영동, 김진철, 홍태균, 황남경, 정환기, 김윤경, 장현욱

[Kisti 연계] 대한약학회 약학회지 Vol.51 No.5 2007 pp.313-317

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A series of luotonin A homologues and their aza-analogues were prepared and evaluated their inhibitory activities on COX-1 and 2 as well as their selectivities on COX-2. The aza-analogue of dimethylene-bridged homologue of luotonin A, 3,3'-dimethylene-2-(1',8'-naphthyrid-2'-yl)-4(3H)-quinazolinone (2b), exhibited strongest inhibitory activity against COX-1 and COX-2 dependent phase of prostaglandin $D_2$ generation in mouse bone marrow-derived mast cells in a concentration-dependent manner with an $IC_{50}$ of 39.3 and $1.89{\mu}M$, respectively. Selectivity of 2b on COX-2 over COX-1 was 21 which implied 2b can be a potential lead for the development of selective COX-2 inhibitor.

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7

가죽나무 에타놀 추출물 및 luteolin-7-O-glucoside의 phospholipase $A_2$ 저해활성

김미화, 황남경, 홍태균, 김윤경, 정환기, 양주혜, 전철구, 배기환, 손건호, 김현표, 강삼식, 장현욱

[Kisti 연계] 한국생약학회 생약학회지 Vol.38 No.3 2007 pp.277-280

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In our continuing effort to investigate compounds having anti-inflammatory activity from natural products, Ailanthus altissima was examined. Among six compounds isolated from Ailanthus altissima, Luteolin-7-O-glucoside (L7G) along with ethanol extract of Ailnathus altissima (EAa) were chosen to determine their inhibitory activity on secretory recombinant phospholipase $A_2s$ enzyme activity in vitro. As a results, EAa inhibited human recombinant $sPLA_2-V$ ($IC_{50}$ of about 100 ${\mu}g/ml$) and $cPLA_2$, ($IC_{50}$ of about 59 ${\mu}g/ml$), while L7G showed strong inhibitory effect on $sPLA_2-A$, V and $cPLA_2$ with an $IC_{50}$ value of approximately 40 ${\mu}M$, respectively.

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8

Platelet Activating Factor Acetylhydrolase의 대량 생산법 개발

정영화, 장현욱, 이태윤

[Kisti 연계] 대한미생물학회 Journal of bacteriology and virology : JBV Vol.36 No.4 2006 pp.229-235

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Platelet activating factor (PAF; 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) is a potent lipid mediator in a variety of physiological events. PAF is also involved in various pathological events including allergy and inflammation. PAF-acetylhydrolase (PAF-AH) hydrolyzes PAF to produce inactive lyso-PAF. Thus, overproduction of PAF-AF will be useful for the therapeutic valuation of the enzyme. In this study, we established an overproduction method of bovine PAF-AH in Escherichia coli system. We used bovine mammary gland for cDNA cloning. The cDNA had two mismatches of amino acid sequences (Thr-247 to Met and Ile-431 to Thr) compared with the previously reported PAF-AH cDNA (bovine spleen, NM_174578). The recombinant PAF-AH of 43 kDa in molecular size reacted with human PAF-AH polyclonal antibody and showed a strong PAF-AH enzyme activity in an in vitro assay system. The recombinant PAF-AH produced by this study can be applied for various experiments including in vivo models to test its protective activity against PAF-related diseases.

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9

단삼 분획추출물의 암예방 효과

손윤희, 조현정, 장현욱, 손건호, 남경수

[Kisti 연계] 한국생명과학회 생명과학회지 Vol.16 No.3 2006 pp.369-374

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본 연구는 단삼 분획추출물로부터 in vitro와 in vivo상에서 QR과 GST의 활성 유도와 GSH의 함량변화를 지표로 암예방 효과를 측정하였다. Hepalcla7 세포에 대한 in vitro상에서의 실험결과 QR 활성 유도율은 70% EtOH 추출물 50 ${\mu}g/ml$ 처리군에서 2.5배로 가장 높은 유도율을 나타내었고, GST 활성 측정은 EtOAc추출물 50 ${\mu}g/ml$농도에서 1.4배의 유도율을 나타내었다. GSH 생성변화를 살펴본 결과에서는 $H_2O$추출물, 70% EtOH 추출물 그리고 water layer 추출물 50 ${\mu}g/ml$ 농도에서 높은 생성율을 나타내었다. 이상의 결과에서 QR활성과 GSH 함량변화에서 높은 증가효과를 나타낸 70% EtOH 추출물을 관류법으로 마우스에 투여하여 in vivo 상에서의 QR과 GST의 활성 변화와 GSH 함량을 측정한 결과 QR, GST활성과 GSH함량이 250 mg 투여시 각각 1.7배 및 1.5배의 활성 증가와 1.4배 함량증가를 측정할 수 있었음으로 70% EtOH추출물은 암예방효과가 가장 높은 것으로 생각된다.
Six fractions of Salvia miltiorrhiza were tested for their chemopreventive potentials using biochemical markers of carcinogenesis such as quinone reductase (QR), glutathione S-transferase (GST) and glutathione (GSH). Seventy percentage of EtOH extract was potent inducer of QR activity in Hepa1c1c7 murine hepatoma cells. GST activity was increased about 1.4-fold with EtOAc extract at concentration of 50 ${\mu}g/ml$. GSH levels were significantly increased with $H_2O$ extract, 70% EtOH extract and water extract at concentration of 50 ${\mu}g/ml$ (p<0.005). From these results, 70% EtOH extract (250 mg/kg) was intragastrically administered to ICR mice for 14 days. QR, GST and GSH levels were significantly increased with the 70% EtOH treatment. These studies suggest that the 70% EtOH extract of S. miltiorrhiza could be considered as a potential agent for cancer chemoprevention.

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10

폴록사머 및 프로필렌글리콜을 이용한 클로트리마졸 고형 좌제의 물리화학적 특성

현경희, 오유경, 김정애, 공경환, 김지현, 양준호, 배명수, 김호동, 이종달, 장현욱, 용철순, 최한곤

[Kisti 연계] 한국약제학회 Journal of pharmaceutical investigation Vol.35 No.2 2005 pp.107-110

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To develop a clotrimazole-loaded solid suppository with poloxamer and propylene glycol, the melting points of various formulations composed of poloxamer 188 (P 188) and propylene glycol were investigated. The dissolution study of clotrimazole delivered by the suppository composed of P 188 and propylene glycol was performed. The mixtures composed of P 188 and propylene glycol were homogeneous. Propylene glycol affected the melting points of poloxamer mixtures. In particular, the mixture [P 188/propylene glycol (70/30%)] with the melting point of about $32^{\circ}C$ was a solid form at room temperature and instantly melted at physiological temperature. Furthermore, propylene glycol affected greatly the dissolution rates of clotrimazole from the suppository. Dissolution mechanism analysis showed the dissolution of clotrimazole was proportional to the time. Our results indicated that the solid suppository with P 188 and propylene glycol would be a candidate of rectal dosage form for clotrimazole.

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11

유색미의 생물활성 검색

한상준, 김주선, 채성욱, 류수노, 현진원, 손건호, 손호용, 장현욱, 강삼식

[Kisti 연계] 한국생약학회 생약학회지 Vol.35 No.4 2004 pp.346-349

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Black colored rice has long been consumed in Oriental countries and is considered to be a healthy food. Extracts from rice with three different colors (white, black, and green) were prepared by using 80% MeOH and subjected to biological screening activities. The levels of antioxidative activity of black colored rice cultivars such as C3GHi and Heugjinjubyeo in radical scavenging activity were higher than those of the related white and green rice ones. When the effect of the extracts on thrombin time inhibition was analyzed, the extract from Heugjinjubyeo showed a dose-dependent suppressive activity. In addition, all the extracts tested did not inhibit the cyclooxygenase activity. Therefore the health benefits of the colored rice are attributed in part to their unique phytochemical composition such as high level of anthocyanin pigments with other minor strong antioxidant components for potential use in neutraceutical or functional food formulations.

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12

대극과 식물로부터 분리한 천연폴리페놀의 멜라닌 생성 억제효과

김정아, 최지영, 손애량, 박성희, 허광화, 이종구, 오인석, 김진준, 장현욱, 정시련, 장태수, 이승호

[Kisti 연계] 한국생약학회 생약학회지 Vol.35 No.2 2004 pp.157-163

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Twenty two polyphenols containing ten gallotannins, seven ellagitannins, two phenylpropanoids and three stilbenes isolated from the higher plants were tested inhibitory effects on melanogenesis in cultured B-16 mouse melanoma cell lines. Among the tested samples, 1-desgalloyleugeniin exhibited the most potent inhibitory effect on melanogenesis in cultured cell lines.

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13

신이(辛夷)로부터 멜라닌 생성 억제물질의 분리

허광화, 김정아, 박성희, 손애량, 장태수, 장현욱, 정시련, 이승호

[Kisti 연계] 한국생약학회 생약학회지 Vol.35 No.2 2004 pp.152-156

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The bioassay-guided fractionation of the MeOH extract of the flowers of Magnolia denudata led us to the isolation of six compounds identified as fargesin(1), kobusin(2), aschantin(3), magnolin(4), rel-[7s,8s,8's]-3,4,3',4'-tetra- methoxy-9,7'- dihydroxy-8,8',7.O.9'-lignan(5) and oplodiol(6), respectively. Among the isolated compounds, fargesin(1) showed most potent inhibitory effect on the melanin polymer biosynthesis in cultured B-16 mouse melanoma cell lines$(IC_{50},\;45.7\;{\mu}M)$.

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14

자생식물을 이용한 미백화장품 개발

이승호, 손종근, 장현욱, 강상진

[Kisti 연계] 대한화장품학회 화장품화학회지 Vol.29 No.1 2003 pp.45-67

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15

한국 자생식물로부터 아라키돈산 대사계 효소 저해제 검색(1)

문태철, 정혜진, 이은경, 박해영, 전수진, 손건호, 김현표, 배기환, 강삼식, 권동렬, 장현욱

[Kisti 연계] 한국생약학회 생약학회지 Vol.34 No.1 2003 pp.109-117

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Arachidonic acid(AA), which is stored in membrane glycerophospholipids, is liberated by phospholipase $A_2(PLA_2)$ enzymes and is sequentially converted to cyclooxygenase (COX) and lipoxygenase (LOX) then to various bioactive prostaglandins (PGs,) and leukotrienes (LTs). In order to find the specific inhibitors of AA metabolism enzymes such as $PLA_2$, COX-2, 5-LO and lyso PAF acetyltransferase. 195 Korean indigenous plant extracts were evaluated for their inhibitory activity on $PGD_2,\;LTC_4$ production from cytokine-induced mouse bone marrow-derived mast cells (BMMC) and arachidonic acid released from phospholipid and PAF production from lyso PAF. From this screening procedure, methanol extract of eight plants such as Saururus chinensis, Aster tataricus, Chrysanthemum cinerariaefolium, Reynoutria japonica, Disocorea nipponica, Epimedium koreanum, impatiens textori, Veronica rotunda var. subintegra were found to inhibit production of inflammatory mediators in vitro assay system.

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개느삼 (Echinosophora koreensis)으로부터 Flavonoid 및 Saponin 성분의 분리

김주선, 변지혜, 손건호, 김현표, 장현욱, 강삼식

[Kisti 연계] 한국생약학회 생약학회지 Vol.33 No.2 2002 pp.110-115

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Seven prenylated flavonoids and two pterocarpans together with a saponin were isolated from the roots of Echinosophora koreensis. They were identical with echinoisosophoranone, echinoisoflavanone, isosophoranone, sophoraisoflavanone A, kenusanone C, kenusanone A, sophoraflavanone D, 4-hydroxy-3-methoxy-(6aR,11aR)-8,9-methylenedioxy-pterocarpans, (-)-maackiain, and $3-O-{\alpha}-L-rhamnopyranosyl(1{\rightarrow}2)-{\beta}-D-galactopyranosyl(1{\rightarrow}2)-{\beta}-D-glucuronopyranosyl$ kuzusapogenol A. Among them, a pterocarpan, 4-hydroxy-3-methoxy-(6aR,11aR)-8,9-methylenedioxypterocarpan, and a saponin, $3-O-{\alpha}-L-rhamnopyranosyl(1{\rightarrow}2)-{\beta}- D-galactopyranosyl(l{\rightarrow}2)-{\beta}-D-glucuronopyranosyl$ kuzusapogenol A, were isolated for the first time from this plant.

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Amentoflavone의 아라키돈산 유리효소인 phopholipase $A_2$에 대한 저해활성 및 비만세포에서 histamine 유리 억제효과

문태철, 이은경, 이승호, 손건호, 김현표, 강삼식, 장현욱

[Kisti 연계] 한국생약학회 생약학회지 Vol.33 No.1 2002 pp.49-52

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Amentoflavone, naturally occurring biflavonoid, isolated from the leaves of Ginko biloba, selectively inhibited human seceretory phospholipase $A_2$. This compound potently and irreversibly inhibited human group IIA in a dose dependent manner with an $IC_50$ about $3\;{\mu}M$. Amentoflavone inhibited phospholipase $A_2$ by a noncompetitive manner with the apparent Ki value of $1{\times}10^{-5}M$. In addition, the inhibitory activity of amentoflavone is rather specific against group IIA phospholipase $A_2$ than group IB phospholipase $A_2$. Furthermore, this compound strong inhibit histamine release from $A_{23187}$ treated rat peritoneal mast cells. These results indicate naturally occurring biflavonoid represents a novel anti-inflammatory agent.

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18

풀명자 뿌리의 성분

허영남, 김주선, 손건호, 김현표, 장현욱, 배기환, 강삼식

[Kisti 연계] 한국생약학회 생약학회지 Vol.33 No.4 2002 pp.267-271

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Prunasin and pomolic acid together with a mixture of ursolic and oleanolic acids, (-)-epicatechin and ${\beta}-sitosterol$ glucoside were isolated from the roots of Chaenomeles japonica. Among these compounds, the isolation of pomolic acid and prunasin is the first report from the genus Chaenomeles.

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19

원추리 지하부의 성분 연구

김주선, 손건호, 장현욱, 김현표, 배기환, 강삼식

[Kisti 연계] 한국생약학회 생약학회지 Vol.33 No.2 2002 pp.105-109

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Besides chrysophanol and friedelin, mixtures of n-hydrocarbons [pentacosane (72.6%), heptacosane (14.6%), tetracosane (5.8%), nonacosane (4.1 %) and hexacosane (2.9%)], n-hydrocarbon alcohols [octacosanol (70.5%) and hexacosanol (29.5%)], l-monoacyl glycerols [acyl part; behenic acid (43.5%), lignoceric acid (32.4%), cerotic acid (9.3%), tricosanoic acid (8.9%), pentacosanoic acid (2.6%), octacosanoic acid (2.3%), heneicosanoic acid (1.0%)], wax esters [behenic acid (56.3%), lignoceric acid (23.0%), cerotic acid (19.8%), tricosanoic acid (4.6%), octacosanoic acid (4.0%), pentacosanoic acid (1.7%), triacontanoic acid (0.6%)/ octacosanol (33.7%), hexacosanol (21.0%), tetracosanol (15.6%), triacontanol (10.5%), docosanol (6.0%), tricosanol (6.0%), heptacosanol (4.2%), nonacosanol (3.0%)] and sterols [${\beta}-sitosterol$ (73.2%), stigmasterol (14.6%), campesterol (12.2%)] were isolated from the roots of Hemerocallis fulva. The acid : alcohol combinations of the major wax esters were $C_{48}$: 22 : 26, 24 : 24, $C_{46}$: 22 : 24, and $C_{44}$: 22 : 22. This is the first report of l-monoacyl glycerols and friedelin from this plant. All isolates were identified on the basis of spectral data and chemical reactions.

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양강으로부터 COX-2 억제활성물질의 분리

김주선, 손건호, 김현표, 장현욱, 강삼식

[Kisti 연계] 한국생약학회 생약학회지 Vol.31 No.1 2000 pp.57-62

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By bioassay-guided fractionation followed by chromatographic separation of the MeOH extract of Alpinia Rhizome, five COX-2 inhibitors were isolated and characterized as pinocembrin, galangin 3-methyl ether, galangin, kaempferid, and 5-hydroxy-7-(4'-hydroxy-3'-methoxyphenyl)-1-phenyl-3-heptanone.

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