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1

메가 이벤트 자원봉사자의 참여동기와 자기효능감, 자아성취감, 만족 간의 영향 관계 : 2018 평창 동계올림픽을 중심으로

신남주, 김해리

관광경영학회 관광경영연구 제22권 제4호 통권 83호 2018.07 pp.355-378

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Volunteers have become particularly vital for the delivery of Mega Events, as most events now depend to some degree on volunteers for event planning and operations. The growing dependence of the event industry on volunteers is aptly illustrated by the significant growth of volunteerism at mega events such as the Olympic Games. The purpose of this study is to investigate the relationship among the participation motives of PyeongChang Winter Olympics volunteers and self-efficacy, self-achievement, and satisfaction and to investigate the factors that can make volunteers experience the satisfaction and the volunteer activities, and to help us recruit volunteers and establish the management strategies. As a result of this study, it was analyzed that the participation motives had a positive (+) influence on self-efficacy. The participation motives had a positive (+) influence on self-achievement. The self-efficacy had a positive (+) influence on self-achievement. The self-efficacy had a positive (+) influence on satisfaction. And the self-achievement had a positive (+) influence on satisfaction.

6,100원

2

여대생의 기능적 다리길이 차이가 런지 자세에서 중간볼기근, 넙다리근막긴장근의 근활성도에 미치는 영향

김해리, 송예진, 문성기, 장현정

대한정형도수물리치료학회 대한정형도수물리치료학회지 제19권 제2호 2013.12 pp.39-46

※ 원문제공기관과의 협약에 따라 모든 이용자에게 무료로 제공됩니다.

Background: The purpose of this study was to realize the relations between gluteus medius, tensor fascia lata of pelvic muscles and functional leg length in women’s university students. This study is examined the change of electromyographic activation on gluteus medius and tensor fascia lata according to the leg length discrepancy. Methods: All of the female of freshman and sophomore in ‘D’college were gathered and separated fourteen of healthy women in two groups by functional leg length discrepancy. and The subjects divided into two groups that the difference with less than 2㎝ or more would have structural defects by tapeline. The electromyographic activation on the gluteus medius and tensor fascia lata muscles were recorded by surface electrodes at maximal voluntary isometric contraction (MVIC) during lunge posture. The collected datas were analyzed using Independent t-test with SPSS win19.0. Results: In intergroup comparison of electromyographic activation levels for gluteus medius and tensor fascia lata in short or long leg, the influence of electromyographic activation on tensor fascia lata is shown to be more statically higher than gluteus medius according to functional leg length discrepancy in coeds. Even though both muscles are shown to be statistically higher in comparison of electoromyographic activation levels for tensor fascia lata and gluteus medius between short leg and long leg in GroupⅠ, Differences of electoromyographic activation levels for tensor fascia lata is shown to be statistically higher than gluteus medius. Conclusion: Through this study, we realized that tensor fascia lata than the long leg, and also, tensor fascia lata is significantly effective for functional leg length discrepancy than gluteus medius. It leads to pelvic lateral instability. This means that cause tensor fascia lata to have a leg length discrepancy.

3

반도체설계교육센터 (IDEC)와 반도체 산업

선혜승, 석은주, 조인신, 김해리, 김연태, 김하늘, 문관식, 김영지, 이의숙, 박인철

[Kisti 연계] 대한전자공학회 電子工學會誌 Vol.44 No.1 2017 pp.49-60

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4

전자상거래 데이터의 실시간 분석을 위한 데이터 스트림과 다수 릴레이션 간의 효율적인 연속 조인 처리 기법

김해리, 이기용

[Kisti 연계] 한국전자거래학회 한국전자거래학회지 Vol.18 No.3 2013 pp.159-175

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최근 들어 전자상거래 데이터의 실시간 공급이 가능해지면서, 전자상거래 데이터를 실시간으로 분석하고자 하는 요구가 급증하고 있다. 이를 위해서는 전자상거래 데이터 스트림과 디스크에 저장된 대규모 릴레이션 간의 연속 조인 질의를 효율적으로 처리하는 것이 매우 중요하다. 본 논문에서는 전자상거래 데이터 스트림과 디스크에 저장된 다수 릴레이션 간의 효율적인 연속 조인 질의 기법을 제안한다. 제안 방법은 기존 방법에 비해 서비스율을 크게 향상시키는 한편, 메모리 사용량을 크게 줄인다. 분석과 다양한 실험을 통해, 제안 방법은 기존 방법에 비해 서비스율과 메모리 사용량에서 더 효율적임을 보인다.
Recently, as real-time availability of e-commerce data becomes possible, the requirement of real-time analysis of e-commerce increases significantly. In the real-time analysis of e-commerce data, it is very important to efficiently process continuous join queries between an e-commerce data stream and disk-based large relations. In this paper, we propose an efficient method for processing a continuous join query between an e-commerce data stream and multiple disk-based relations. The proposed method improves the service rate significantly, while reducing the amount of required memory substantially. Through analysis and various experiments, we show the efficiency of the proposed method compared with the previous one in terms of service rate and memory usage.

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5

이동통신 산업기술 동향과 연구개발 정책방향

이현우, 김상태, 박인성, 허창회, 김근대, 김해리

[Kisti 연계] 한국통신학회 정보와 통신 Vol.28 No.2 2011 pp.3-9

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이동통신산업은 대규모 R&D 비용과 고위험으로 기술 및 시장 진입 장벽이 매우 높고, 호환성(backward compatibility) 제공 문제로 후발 주자들이 쉽게 뛰어들기 힘든 산업이다. 하지만 성장 잠재력이 크고 타산업간 융합의 Keyfactor가 되는 산업이다. 본고에서는 이동통신 산업의 특성을 파악하고, 표준화 동향, 이동통신 분야 정부 R&D 추진현황 및 향후 추진방향에 대해 알아보고 마지막으로 정부 R&D 기획 프로세스를 통하여 기술수요조사 결과가 하나의 연구개발과제로 생성되는 과정에 대해 알아본다. 결론에서는 이동통신 산업에 대한 미래 전략을 통해 앞으로의 이동통신 산업이 나아갈 길을 제시하고자 한다.

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6

청주시(淸州市) 웃방꺾음집의 생활공간(生活空間) 변용(變容)에 관한 조산연구(調査硏究) - 안방과 부엌을 중심으로 -

김해리, 김태영

[Kisti 연계] 한국주거학회 Journal of the Korean housing association Vol.20 No.6 2009 pp.19-29

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The purpose of this study is to clarify the spatial changes that have taken place in the main rooms (Anbang) and kitchens of traditional Utbangkkeokeum houses in Cheongju city, located on the central inland of Korea. These houses consist of a main house (Momchae) and a single-wing house (Nalgaechae), creating an ㄱ-shaped plan. The kitchen is in the front of the Nalgaechae, and the Anbang is at the rear. For the Momchae, the main hall (Daechung) is next to the Anbang, which is at the end of the Nalgaechae, and the room (Gunnunbang) is situated across from the Daechung. This study is based on the assumption that these houses have been conserved and altered from their original forms. As a result of alterations, many changes have occurred to the main room and kitchen spaces. The traditional main room is connected with two rooms (Utbang and Araebang), new standup kitchens are introduced, and floor heating systems are installed. The Anbang has maintained its sedentary lifestyle and the space for major daily activities such as sleeping and TV viewing. Also, TV viewing is a distinctive feature for residential purposes and the bedding is located in such a position that it is easy to observe any exterior movement for the elderly living alone. The layout of the standup kitchen has been altered to maintain the previous circulation, position and function of the entrance. Also, the kitchen and dining room were used together, and the size of these rooms has been partially increased from the original module in different ways for each case. The above findings suggest that Utbangkkeokeum houses of Cheongju city have been spatially changed while maintaining the previous lifestyle.

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7

청주 구도심내 주택유형별 분포 및 규모특성에 관한 연구

김해리, 김태영

[Kisti 연계] 한국주거학회 한국주거학회 학술대회논문집 2008 pp.125-130

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The new apartments has been rapidly built through the outskirts of Cheong-ju city since the latter half of 1980's. So, the population decreased in Seong-an dong and Jung-ang dong which are located in traditional urban area of Cheong-ju. Also, residential areas became obsolete and residential buildings happened to be vacant and empty. For urban rehabilitation, the city authorities will construct the high-rise complex housings with stores in the traditional urban area. We have doubts about whether the rapid change of new housing construction is right or not. Therefore, It is necessary to give a correct diagnosis of the present state from urban atrophy, keeping this area sustainable with traditionality and locality. This study is to examine and analysis in detail distribution patterns and habitable floor area by house types in Seong-an dong and Jung-ang dong which are located in traditional urban area of Cheong-ju. The result are as follows; the residential buildings as the 2,680 houses(including detached and apartment houses) and the 804 shop houses are distributed with 3,484(67%) of the whole 5,183 buildings and form 28percent of the whole floor areas. A distribution and area ratio of houses to shop houses is irrespectively about 76 : 24percent. The average floor area is represented with $66m^2$/household and $28.5m^2$/person. It shows that a hollowing out of urban area has caused the surplus of residential buildings and floor areas.

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8

A Case Study on the Exhibition Reuse of Korean Traditional Houses designated as Modern Cultural Heritage -Focused on Rhiwhachang.Choi Sunu House-

김해리, 이민경, 김태영

[Kisti 연계] 한국주거학회 한국주거학회 학술대회논문집 2008 pp.156-161

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The registered-properties guideline was adopted to preserve the facade of existing cultural assets with effect and alter the interior space freely. But many problems have been occurred over all the converted buildings with the passing of the years as a result of unfeasible design guidelines. Accordingly, the thesis is to propose the problem and assignment in a setting for a display through the conversion for exhibition of Korean traditional houses designated as modern cultural heritage focused on Riwhachang Choi Sunu House. The results are as follows; The exhibition circulation is continuously connected with each room, considering the previous life-style. The interior design elements are preserved according to the stand-up and sitting style. It is possible to put on one sided wall display in stand up style(Rhiwhachang), and island showcase display in sitting style(Choi Sunu House). And also these apparatus is suitable for the existing window pattern and frame. Therefore, this study is to suggest an assignment of design guideline for exhibition reuse in Korean Traditional Houses as well as the sustainable preservation of cultural assets as modern house.

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9

플라즈마 표면 처리된 박막의 Si-DLC 시간에 따른 젖음각 거동

이진우, 김해리, 문명운, 이광렬, 김석삼

[Kisti 연계] 한국진공학회 한국진공학회 학술대회논문집 2008 p.165

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10

기-액 복합 광반응기에서의 악취성 암모니아 제거를 위한 촉매개발과 반응시스템의 최적조건 색출 연구

김해리, 전민규, 김준우, 주광태, 정석진

[Kisti 연계] 한국대기환경학회 한국대기환경학회지 Vol.24 No.5 2008 pp.512-522

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Ammonia is a major compound of odor in livestock house. To enhance the performance of ammonia oxidation (decomposition). the gas-liquid, two phase photocatalytic oxidation system was designed and prepared in this study. Commercial P-25 as $TiO_2$ catalyst was used for ammonia decomposition. V/P-25 catalyst prepared by sol gel method was also used for the removal of by-producted $NO_x$ in $NH_3$ oxidation reaction. When $TiO_2$ was used as a photocatalyst, the conversion to $N_2$ in ammonia decomposition reached above 90% until 200hr (The air flow rate of 4L/min with the ammonia concentration up to 25ppm.). However, considerable amounts of NO and $NO_2$ were formed as a result of $NH_3$ oxidation (as a by-product). Therefore, we added Vanadia impregnated $TiO_2$(P-25) catalyst for the removal of $NO_x$ at the end of reaction trail. The results of a pilot-scale operation were successful to achieve the simultaneous removal of $NH_3\;and\;NO_x$ about 81 and 87%, respectively.

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11

매복된 상악 전치의 교정적 치료 : 증례보고

김해리, 오소희, 김영희

[Kisti 연계] 대한소아치과학회 대한소아치과학회지 Vol.34 No.4 2007 pp.709-717

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상악 전치의 매복은 제3대구치, 상악 견치, 상하악 제2소구치에 비해서 드물지만, 정중 과잉치, 외상, 치근만곡 등의 치근형성의 변이가 높은 빈도로 나타나기 때문에 다른 전치부에 비해서는 매복되는 비율이 높고, 보통 약 8세 이후의 초기 혼합치열기의 아동에서 관찰된다. 상악 중절치의 매복으로 인한 인접치아의 이동으로 공간상실과 함께 정중선 변이가 나타날 수 있고 낭종 등이 발생할 수 있으므로, 정확한 위치를 확인하고 적절한 치료 계획을 세우는 것이 중요하다. 치료 방법으로는 외과적 발거, 자발적 맹출의 관찰, 교정적 견인 등이 있으나, 매복치의 병적 변화가 없고, 치근의 발육이 양호하다면 기능과 심미성의 회복을 위해 교정적 견인을 시행한다. 이에 매복된 상악 전치들을 교정적 견인을 통해 정상적인 맹출방향으로 유도하여 양호한 치료결과를 얻었기에 보고하는 바이다.
Impaction of maxillary incisor is rare than the third molar and canine, but its rate is higher than the other anterior teeth due to frequent mesiodens, trauma and variation of root formation (root dilaceration etc.). It is often observed in the dental age of about eight years and over. It will be occurred that the space loss, midline deviation and cyst formation due to the impaction of maxillary incisor. So it is important to evaluate the precise location of impacted tooth and to make appropriate treatment plan. Treatment would be surgical extraction or expectation for spontaneous eruption. If the impacted tooth has no pathologic change and development of the root is favorable, orthodontic traction is recommended for recovery of function and esthetics. In these cases, we performed orthodontic traction for the eruption of impacted maxillary incisors, and obtained satisfactory results.

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12

외상에 의해 함입된 치아의 교정적 견인을 통한 치험례

김해리, 오소희, 김영희

[Kisti 연계] 대한소아치과학회 대한소아치과학회지 Vol.34 No.3 2007 pp.506-512

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어린이에서 치아의 외상성 손상은 흔히 일어나는 문제이며, 손상 부위 및 정도에 따라 치아의 파절, 치주조직의 손상, 지지골 조직의 손상, 연조직의 손상 등으로 분류할 수 있다. 치주조직의 손상 중 치아가 외상에 의해 함입된 경우는 상악전치부에서 흔하며, 다른 유형의 손상에 비하여 비교적 발생빈도가 낮은 편이지만, 치축방향으로 충격이 가해져 치수뿐만 아니라 지지조직까지 손상을 일으킨다. 치아의 함입에 대한 치료 방법으로는 유전치나 조금 함입된 미성숙 영구 전치의 경우, 인위적인 재위치 없이 3-4주 동안 재맹출을 기대할 수도 있으나, 심하게 함입되어 재맹출을 기대하기 어려운 영구 전치의 경우에는 교정적 견인을 통해 교합수준에 이르게 하는 것이 일반적인 방법이며, 고정성/가철성 장치를 이용할 수 있다. 이때에는 약하고 지속적인 힘을 이용하여 치아를 치관방향으로 이동시킨다. 자발적 재맹출, 교정적 견인이 불가능 한 경우에는 외과적으로 치아를 재위치 시키고 주기적으로 관찰하는 방법이 있다. 이에 외상으로 인해 상악 좌측 영구 중절치가 함입되어 내원한 8세 7개월과 9세 11개월의 환아에서, 치수 괴사에 대한 통상적인 근관치료와 고정성 장치를 이용한 교정적 견인을 통해 양호한 치료 결과를 얻었기에 보고하는 바이다.
Traumatic injury of tooth in children is commonly occurred problem. It is classified into tooth, periodontal tissue, supporting bone, soft tissue injury by it's area and extent. Among the periodontal tissue injuries, traumatically intruded teeth are common in anterior maxillary area, though the occurrence rate is rather low, the pulp and supporting tissue injury is possible by vertical impact. The treatment method of traumatically intruded teeth is various. Observation on the spontaneous reeruption for 3-4 weeks is recommended if the traumatized teeth are deciduous teeth or slightly intruded immature permanent anterior teeth. If this did not occur because the extent of intrusion is severe or the traumatized teeth are mature permanent anterior teeth, orthodontic traction is applied by fixed/removable appliances. At this time, light and continuous force is applied for the extrusive movement of the intruded teeth. When above procedures are impossible, surgical repositioning and fixation is recommended. In these cases, we performed conventional endodontic therapy for pulp necrosis and orthodontic traction with fixed appliance. We obtained satisfactory results and will report that.

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13

대두유와 쌀눈기름의 급여가 인슐린 의존형 당뇨 마우스의 지질대사에 미치는 영향

이성현, 전혜경, 박홍주, 이연숙, 김해리, 승정자

[Kisti 연계] 한국지역사회생활과학회 한국지역사회생활과학회지 Vol.14 No.2 2003 pp.83-92

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This study was carried out to investigate the supplementary effects of soybean oil and rice gem oil compared with lard on lipid metabolism of insulin dependent diabetic mice. Streptozotocin-induced diabetic mice were fed three kinds of experimental diets with 20% lipid from lard(L), soy bean oil(SBO) and rice gem oil(RGO) for 7 weeks, respectively. Diet intake, body weight, organs weights and lipids levels of serum, liver and feces were measured. There was no significant difference in diet intake, body and organs weights among experimental groups. But the concentrations of serum triglyceride of SBO and RGO groups, and of serum total cholesterol were lower in RGO group than in the other groups. The hepatic total lipid and total cholesterol levels of RGO group were significantly lower than those of the other groups. The contents of total lipid and total cholesterol excreted in feces of SBO and RGO groups were higher than those of L group, and the significance was shown only in RGO group. These results suggested that soy bean oil and rice germ oil can reduce serum triglyceride and total cholesterol levels and hepatic total lipid concentration of insulin dependent diabetic mice compared with lard as a animal fat source by increasing fecal lipid excretion of these groups. But the significant reducing effects on serum and liver lipid levels were shown only in RGO group, and we need to investigate the hypolipidemic effect of this oil by supplementary level and period.

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트립토판 보강식이를 섭취한 마우스에서 serotonin 대사와 morphine 진통기작 관련성에 대한 연구(II)

권영혜, 이윤옥, 김해리

[Kisti 연계] 한국응용약물학회 Biomolecules & therapeutics Vol.9 No.1 2001 pp.20-25

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In this study we fed control diet and tryptophan supplemented diets containing 0.35% tryptophan to ICR mice for 2 weeks. The concentrations of serotonin and 5-HIAA were changed by injection of the serotonin synthesis inhibitor, p-CPA and the serotonin precursor, serotoninP and the change of brain serotonin concentration negatively correlated with that of pain sensitivity, and p-CPA and serotoninP also changed the analgesic effect of morphine. The injection of naloxone, the opiate antagonist, resulted in an increase in the writhing frequency, but its antagonistic effect was not significant. The concentration of 5-HIAA elevated in mice brain at least 3hr after administration of morphine hydroxide indicates that the changes in brain serotonin metabolism may be associated with the acute effects of morphine analgesia. In short, these results not only suggest that tryptophan supplemented diet suppress pain sensitivity in mice, but also indicate that at least in part analgesic mechanism of serotonin may be associated with morphine analgesia.

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트립토판 보강식이를 섭취한 마우스에서 serotonin 대사와 orphine 진통기작 관련성에 대한 연구(I)

권영혜, 이윤욱, 김해리

[Kisti 연계] 한국응용약물학회 Biomolecules & therapeutics Vol.8 No.4 2000 pp.311-317

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In this study we fed control diet and tryptophan supplemented diets containing 0.1,0.2,0.35% tryptophan to ICR mice for 1∼3 weeks to investigate the effects of tryptophan supplemented diet on pain sensitivity and the analgesic mechanism of serotonin. Animals fed tryptophan supplemented diets displayed increased antinociception when measured with hot plate and phenylquinone-writhing tests. And animals with typtophan supplemented diet had higher brain serotonin and 5-HIAA concentration than the control animals.

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16

두릅나무와 황백피의 혼합추출물 P55A의 랫트 및 개에 대한 경구투여 급성독성

강부현, 손화영, 송시환, 차신우, 서동욱, 정영신, 홍은경, 김해리

[Kisti 연계] 한국응용약물학회 Biomolecules & therapeutics Vol.7 No.2 1999 pp.185-190

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The current study was performed to determine the acute oral toxicity of P55A, a crude extract of 1 : 1 mixture of Phellodendron amurense cortex and Aralia elata cortex, in SD rats and beagle dogs. 5 rats of each sex were treated with a single dose of P55A orally at doses of 0 and 5,000 mg/kg respectively. Also 2 dogs of each sex were treated with a single dose of P55A orally at doses of 0 and 2,000 mgAg, respectively. After the treatment, clinical signs, and body weight change were observed for 14 days. All rats survived during the study and did not show any clinical sign. Body weight gain showed no significant difference between the control and treated rats. Grossly, no lesion was observed in the rats. All dogs survived during the study. In clinical signs, dark stool was observed in the 2,000 mg/kg treated dogs at day 1 after administration. The animals recovered from general signs at day 2 after administration. Body weight gain showed no significant difference between the control and treated dogs. Grossly, no lesion was observed in the dogs. It is suggested that the LD$_{50}$ of P55A by oral administration was estimated to be over 5,000 mg/kg in both sexes of rats and 2,000 mg/kg in both sexes of beagle dogs.s.

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비타민 E 보강식이가 KK마우스에서 간조직의 항산화계 효소 활성도에 미치는 영향

김해리, 안현숙, 서소영

[Kisti 연계] 한국식품영양과학회 한국식품영양과학회지 Vol.27 No.1 1998 pp.149-156

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The purpose of this study was to investigate the effects of vitamin E supplementation on the activities of antioxidative enzymes in liver of KK mice of various ages and various duration of diabetes. Diabetes was induced by feeding high fat diet containing 20% corn oil(wt/wt). Weaned KK mice were fed high fat diet containing 51 IU or 2080 IU vitamin E per kg diet. Animals were sacrificed at 4, 6, and 9 months of age. In nondiabetic group, we found the decrease of antionxidative enzyme activities with aging. In diabetic group, antioxidative enzyme activities were decreased, and the change of hepatic vitamin E was related to glutathione peroxidase activity (r=0.71, p<0.001). Treatment with vitamin E did not modify the level of fasting blood glucose. However, it was observered that glutathione reductase and glutathione peroxidase activities as well as hepatic glutathione levels were increased by vitamie E supplementation, whereas catalase activity did not changed. The present result suggest that high vitamin E supplementation protects against lipid peroxidative damage in diabetic KK mice.

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Astaxanthin을 포함한 Red Yeast를 급여한 무지개 송어 간과 근육의 Astaxanthin, $\alpha$-Tocopherol 및 지질과산화물 함량

김해리, 강지원

[Kisti 연계] 한국식품영양과학회 한국식품영양과학회지 Vol.27 No.5 1998 pp.935-939

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The concentrations of astaxanthin and $\alpha$-tocopherol were measured from the muscle of the rainbow trout(Oncorhynchus mykiss) that had been fed the red yeast(Phaffia rhodozyma) containing 0.2% astaxanthin for 7, 14 and 21 days. The effect of the astaxanthin supplementation for 21 days on peroxidation of liver and muscle lipids of the rainbow trouts was examined. The astaxanthin was found to be accumulated in the rainbow trout muscle when fed for 7 days with astaxanthin supplementation(80mg/kg diet) in the form of the red yeast and the content did not increase further when fed longer up to 21 days. Seven days supplementation of astaxanthin raised the rainbow trout muscle content of the astaxanthin to 17.3$\mu\textrm{g}$/g tissue from 11.8$\mu\textrm{g}$/g tissue in mature control group. Although the hepatic TBARS level was found to be significantly decreased, the astaxanthin supplementation did not alter the $\alpha$-tocopherol and TBARS contents of the rainbow trout muscle.

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19

당뇨 KK마우스에서 비타민 E 보강식이가 신장 당화단백질 생성에 미치는 영향

안현숙, 박성연, 김해리

[Kisti 연계] 한국영양학회 Journal of nutrition and health Vol.31 No.6 1998 pp.1024-1030

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KK마우스에 고지방 식이를 섭취시켜 당뇨를 유발하고, Maillard 반응의 초기산물인 Hb $A_{IC}$와 후기 산물인 신장조직의 CLF가 증가되는지를 확인하고. 당뇨병에 의해 증가되는 Maillard 반응이 비타민 I의 투여로 억제되는지 관찰하였다. 또 신장조직의 광학 현미경 관찰을 통하여 신장병변을 검사하였다. 이유즉시 KK마우스를 1개월간 pellet diet로 적응시킨 후 저비타민 E 식이(corn oil 20%, wt/wt)를 먹여 당뇨를 유도하였다. 비타민 E 보강은 2080IU/kg diet 수준으로 하였으며. 생후 4개월 , 6개월 . 9개월(당뇨 0개월. 2개월, 5개월)에 희생시켰다. 정상 KK-마우스에서는 월령이 증가하였을 때. 혈당과 Hb $A_{IC}$는 유의적인 변화를 보이지 않았으나 신장조직의 CLF는 점진적으로 증가되었다. 당뇨군에서 Hb $A_{IC}$는 6개월에서 증가되기 시작하였고 9개월군과 차이가 없었으며 . 신장조직의 CLF는 9개월 군에서 급격히 증가하였다. 또 고비타민 E 식이를 섭취시킨 경우 당뇨군에서 초기 및 후기 Maillard 반응생성물의 감소가 관찰되었다. 이상의 결과로부터 KK마우스에서는 월령이 증가함에 따라 초기 및 후기 당화산물의 축적과 신장 병변의 변화가 관찰되었고, 또한 당뇨 유발에 의해 이 변화들은 더욱 촉진되었으나, 2080IU/kg diet 수준의 고비타민 E 식이를 섭취시켰을 때 이런 변들이 억제되었음을 확인하였다.확인하였다.
We investigated the effects of vitamin E supplementation on protein glycosylation in early and end stage product, and light microscopic studies were done on the renal glomeruli of KK-mice of various ages and various duration of diabetes. Weaned KK-mice were fed high fat diets containing 20% corn oil(wt/wt), and sacrificed at 4,6, and 9 months of age. The high vitamin E diet was a high fit diet supplemented with an excess amount of d1-$\alpha$-tocopheryl acetate (2080IU/kg diet). We measured Hemoglobin $A_{IC}$ (Hb $A_{IC}$) as a glycosylation early product, and renal collagen-linked fluorescence as a glycosylation end product. In the diabetic group, levels of Hb $A_{IC}$ were increased within 2 months after onset of diabetes and remained at a constant level for the duration of experiment. 5 months after onset of diabetes, renal collagen linked fluorescence(CLF) was markedly increased. A quantative, morphologically demonstratable, progressive thickening of the basement membrane and calcification occured in the diabetic KK-mice. There is a statiscally positive correlation between CLF and histologic grade of diabetic nephropathy. Hepatic vitamin E levels correlated with those of Hb $A_{IC}$, renal CLF, and renal calcification. Treatment with vitamin I did not modify the level of blood glucose. However, we observered a significant lowering of CLF and Hb $A_{IC}$ in diabetic mice. Supplementation of vitamin E was found to delay the progression of diabetic nephropathy. (forean J Nutrition 31(6) : 1024-1030, 1998)0, 1998)

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비타민 C의 보강이 당뇨쥐의 간 소포체와 미토콘드리아의 Cytochrome P450계에 미치는 영향

정연재, 임은영, 김해리

[Kisti 연계] 한국식품영양과학회 한국식품영양과학회지 Vol.26 No.4 1997 pp.682-688

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본 논문에서는 당뇨에 의한 CYP2El의 유도와 이에 따른 지질과 산화의 증가에 비타민 C가 미치는 영향을 간 소포체와 미토콘드리아에서 알아보고자 하였다. Cy-tochrome P450의 함량은 간 소포체와 미토콘드리아 모두에서 정상과 당뇨간에 차이를 보이지 않았고, 비타민 C의 공급은 영향이 없었다. Superoxide anion에 의한 지질과 산화에 가장 큰 영향을 끼친다는 CYP2El에 대하여 immunoblotting으로 그 함량을 알아본 결과, 간 소포체 CYP2El이 당뇨에서 증가하고 비타민 C의 보강은 50mg/d의 공급으로도 현저한 감소를 보여 간 소포체 P450의 함량과는 다른 결과를 나타냈다. 간 미토콘드리아의 경우 소포체와 동량(20$\mu\textrm{g}$)의 단백질을 loading하였는데 CYP2El의 발현을 볼 수 없었다. 간 소포체와 미토콘드리아 NDMA demethylase의 활성이 정상군과 당뇨군에서 유의적인 차이를 보이지 않았으나, 250mg/d의 비타민 C 공급시 간 소포체에서는 유의적으로, 간 미토콘드리아에서는 유의적이지는 않으나 감소하였다. NDMA demethylase의 활성은 CYP1El의 함량을 반영한다고 알려져 있는데 본 연구에서는 동일한 pattern으로 진행되지는 않은 듯하다. NADPH-cyto-chrome c reductase의 활성은 NDMA demethylase의 활성과 양의 상관관계를 보였다. 따라서, 비타민 C의 공 급은 당뇨에 의한 CYP2El의 유도를 감소시키고 NDMA demethylase, NADPH-cyto-chrome c reductase와 같은 약물대사계 효소의 활성을 감소시켜 지질과 산화를 낮출 것으로 사료된다 그러나, 비타민 C의 공급량에 따라 조금씩 다른 결과를 보여 당뇨에 있어 가장 좋은 효과를 보일 수 있는 최적의 비타민 C 보강량을 결정하는 연구가 요구된다. 당뇨군에서 지질과 산화의 지표인 thiobar-bituric acid reactive substances(TBARS)의 함량이 간 소포체에서 유의적으로 증가하였고, 비타민 C의 공급랑에 의존하여 TBARS의 함량이 감소하였다. TBARS의 함량은 NDMA demethylase의 활성과 양의 상관관계를 보여 CYP2E1이 당뇨의 지질과 산화에 영향을 끼친다고 생각된다. 이러한 비타민 C의 항산화 효과는 비타민 C 자체의 항산화 능력, 비타민 E와 glutathione 같은 다른 항산화제의 절약 효과, CYP2El의 유도 저하를 통하는 것으로 생각되며 그중 어떤 것에 가장 큰 영향을 받는 지는 아직 알려지지 않았고 더욱 많은 연구가 요구된다.
This study was performed to investigate whether ascorbic acid can modulate the induction of CYP2E1 and prevent the lipid peroxidation which may cause diabetic chronic complication. Diabetes was induced by intraperitoneal injection of streptozotocin to 5-week-old male Sprague-Dawley rats(150~170g). Normal and diabetic group was randomly divided into three groups each; Control(CON, no supplementation), SUP1 (50mg/d ascorbate supplementation) and SUP2(250mg/d ascorbate supplementation). Ascobic acid was prepared daily by dissolving in drinking water and supplied for 4 weeks. There was no difference in hepatic microsomal and mitochondrial P450 contents between normal and diabetes. Hepatic microsomal N-nitrosodimethylamine(NDMA) demethylase activity, which repre-sents contents of CYP2E1, was elevated in diabetes, but not significantly. The NDMA demethylase activity of diabetic SUP2 group was significantly lower activity than that of the diabetic CON group. However, no difference in hepatic mitochondrial NDMA demethylase activity was observed between the diabetes and the normal group. The result suggests that the induction of CYP2E1 in diabetes can be alleviated by ascorbic acid supplementation at the dose of 50mg1d. In addition, ascorbic acid supplementation showed dose-dependent reduction of hepatic microsomal TBARS contents in diabetic rats.

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