Earticle

Aiming at the characteristics of high dimension and small samples in microarray data, this paper proposes a selective ensemble method to classify microarray data. Firstly, kruskal-wallis test is used to filter irrelevant genes with classification task and to obtain a set of genes, and then a reduced training set is produced from original training set according to gene subset obtained. Secondly, multiple gene subsets are generated by using neighborhood rough set model with different radius and used to construct training subsets on above reduced training set. Thirdly, every constructed training subset is used to train a classifier by using SVM algorithm, and then multiple classifiers are produced as base classifiers. Finally, a set of base classifiers are selected by using teaching-learning-based optimization and build an ensemble classifier by weighted voting. Five benchmarks tumor microarray datasets are applied to evaluate performance of our proposed method. Experimental results indicate our proposed method is very effective and efficient for classifying microarray data, and it improves not only classification accuracy, but also decrease memory costs and computation times.