Earticle

2001년 9월 11일 테러 이후 초국가적 범죄와 테러리즘의 증가로 인해 국경안보의 중요성이 강조됨에 따라 통합적인 CI Q 역량강화가 요구되고 있다. 미국, 캐나다, 호주는 CIQ를 통합하여 여행자·물품 출입국통제 강화 및 공항만·육로 국경보안에 중점을 둔 국경안보 활동을 강화하고 있다. 미국은 2003년 국토안보부 산하에 관세국경관리청(CBP)을 신설하였다. 캐나다도 2003년 공공안전부 산하에 국경보안청(CBSA)을 창설하였다. 호주도 2015년 이민국경보호부(DIBP) 산하로관세국경보호청을 통합하고, 국경수비대(ABF)를 신설하였다. 그러나 CIQ 업무별 분산된 국경관리체계를 운영하고 있는한국은 공항만·육로 국경에서 발생하는 불법 출입국, 테러분자 입국, 밀수입, 마약·총기류 밀거래 등 복합적인 국경위협에통합적으로 대응하기 어렵다. 이를 해결하기 위해서 유사성이 높은 세관 및 검역 업무부터 순차적으로 통합하고, 중장기적으로 관세청이 출입국관리 업무를 위임받아 CIQ 업무 전체를 통합하는 방안도 검토해볼 수 있다. 또는 미국, 캐나다, 호주의 CIQ 단일책임기관을 한국의 실정에 맞게 벤치마킹하여 새로운 통합국경안보조직을 신설하는 방안도 있다.

Since the September 11, 2001, transnational crimes and terrorism have increased, the importance of border s ecurity has been emphasized and integrated CIQ capability has been required. The U.S., Canada, and Australia are consolidating CIQ to strengthen border security, focusing on strengthening travelers and goods immigration contr ol and airports, ports and land border security. In 2003, the U.S. established the Customs and Border Protection(CB P) under the Department of Homeland Security. Canada also established the Canada Border Services Agency(CBSA) under the Public Safety Canada in 2003. The Australian Customs and Border Protection Service was integrated with the Department of Immigration and Border Protection(DIBP) and the Australian Border Force was established in 201 5. However, Korea operates a distributed border management system for each CIQ task which is unable to respond to complex border threats such as illegal immigration, entry of terrorists, smuggling of drugs, and gun trade in the airports, ports and land borders. In order to solve this problem, it is possible to consider integrating sequentially the customs and quarantine services which have high similarities, and to integrate the entire CIQ tasks with the Korea Customs Service delegated to the immigration control duties in the mid to long term. There is also a plan to bench mark the CIQ single accountability agencies in the U.S., Canada, and Australia in accordance with the Korean situati on and to establish a new integrated border security organization.

Objective : We aimed to identify the effects of Bogimakseong-bang(BGMSB) treatment on cBSA-induced MN in a mouse model. Methods : We divided 20 mice into 4 groups. The normal group (NR) had no treatment. We used cBSA to induced MN to the other 3 groups. One group (CT) was treated with cBSA (7mg/kg i.p) only. The second (BG-250) was treated with cBSA (7mg/kg i.p) and BGMSB extract (250mg/kg, p.o). The third group (BG-500) was treated with cBSA(7mg/kg i.p) and BGMSB extract (500mg/kg, p.o). After cBSA and BGMSB extract treatment for 4 weeks, proteinuria, serum albumin, total cholesterol, serum creatinine, BUN, total nucleated spleen cell number and total infiltrated kidney cell number of all groups were measured. CD3e+/CD19+ and CD4+/CD8 cells ratio of peripheral blood, kidney and spleen of all groups were analyzed. $IL-1{\beta}$ and $TNF-{\alpha}$, IL-6, IgG, IgM, and $IFN-{\gamma}$ levels of all groups were gauged. Histological analysis of kidney tissue and immunohistochemical staining (CD4 CD8) of kidneys were observed. Results : Proteinuria significantly decreased and serum albumin increased in groups treated with cBSA and BGMSB extract compared with the control. Total cholesterol decreased but not significantly. CD3e+/CD19cells ratio of peripheral blood decreased. CD3e+/CD19+ and CD4+/CD8 cells percentage of kidney and spleen showed no significant change. Level of $IL-1{\beta}$, $TNF-{\alpha}$ and IL-6 significantly decreased. and $IFN-{\gamma}$ increased but has not significantly. Concentration of IgG and IgM significantly decreased compared with control. Thickness of GBM decreased on histological analysis of kidney. Deposition of CD4 and CD8 decreased on immunohistochemical staining of kidney. Conclusions : According to the above result, BGMSB had a significant effect for treating MN which is cBSA-induced.