Earticle

Objectives : We developed and proposed a guideline for safety and performance assessment of electric cupping apparatus(Class 2 medical device). Methods : We drafted the guideline for safety and performance assessment of electric cupping apparatus by referring the existing standards and guideline, based on online questionnaire for Korean medical doctors and measurement data from commercially available products. Physical dimension of cups and inner vacuum pressure were acquired for the measurement in order to achieve the purposes. Results : This guideline only can be applied to electric cupping apparatus for enhancing blood circulation by employing negative pressure generated by electricity. Seven items of appearance and label, operation test of pump, variation test of input electricity, vacuum level test, vacuum sustain test, cup-size dependent test, noise level test are suggested for evaluation subjects and methods required for electric cupping devices. Requirements for the design and development of electric cupping devices are suggested: vacuum level indicator, vacuum generation rate, pressure control, valve detachment stability, cup comparability, safety measure, surge protection, user friendliness, instruction for use (IFU). Conclusions : We proposed a guideline for safety and performance assessment of electric cupping apparatus to improve the quality of relating products and aid the commercialization of them, by aiming higher industrial competitiveness of the medical device sectors in Korea. Discussion with related institutes such as industry, academy and government is further required. Public hearings also need to be held prior to the establishment of a final guideline and standard.

Adlay, barley and rice bran were extracted using various concentrations of methanol(10% and 80%) and chloroform : methanol(2 : 1) to examine the biological activities of these raw grains. Extraction with 80% methanol resulted in high Vitamin C Equivalent Antioxidant Capacity(VCEAC), in the order of barley > rice bran > adlay, as determined by DPPH and ABTS assays. In addition, the extracts of adlay and rice bran showed high cellular antioxidant activity in HepG2 cells possibly due to the presence of polyphenol glycosides in these grains. We examined the expression of glucose/fatty acid metabolizing genes in differentiated 3T3-L1 adipocyte cells. Glut1 was downregulated after treatment with rice bran and no changes in the expression of Glut4 was observed. In contrast, genes involved in fatty acid metabolism, CD36 and aP2, were upregulated. Since these physiological changes were matched with peroxisome proliferator activating receptor $\gamma$(PPAR $\gamma$) agonism, we suggest that the extracts from adlay, barley and rice bran may play preventive roles against aging and diabetes via antioxidant activity and increased uptake of fatty acids by adipocytes.

1. Objectives: The aim of this study was to survey the tendency of perspiration and health condition of Sasang Constitution and to analysis the relationship between health condition and perspiration. 2. Methods: We recruited 1565 subjects in multi-oriental hospitals and researched their perspiration and health condition. Subjects were diagnosed by the Sasang Constitutional specialists in oriental hospitals, and had remarkable improvement in their chief complains after Sasang Constitutional Medication. All subjects answered the questionnaire about the tendency of perspiration including the amount and region of sweating, and the health condition such as meal, appetite, tiredness, health degree, and warm-cold preference. Based on these clinical data, we analyzed the Sasang Constitutional deviation of health condition according to the tendency of perspiration. We found the differences of answering using Chi-square test between-group comparison. We analyzed using SPSS 14.0 for Korean. 3. Results: The amount of sweating was related with degree of health condition such as tiredness, health degree, meal, appetite, and warm-cold preference. However there was no significant differences between Sasang Constitutional groups. 4. Conclusions: According the region of sweating, there was some deviation of health conditions between Sasang Constitution. Especially sweating of head and neck meant good symptom for SE type but not for SY type. And the sweating on the chest and axilla meant bad symptoms for all Sasang Constitutional types.

This paper introduces an automatic voice classification system for the diagnosis of individual constitution based on Sasang Constitutional Medicine (SCM) in Traditional Korean Medicine (TKM). For the developing of this algorithm, we used the voices of 473 speakers and extracted a total of 144 speech features from the speech data consisting of five sustained vowels and one sentence. The classification system, based on a rule-based algorithm that is derived from a non parametric statistical method, presents binary negative decisions. In conclusion, 55.7% of the speech data were diagnosed by this system, of which 72.8% were correct negative decisions.

We intended to identify the health state of Oriental medical students and also to know how many things of health practice are in healthy group and non-healthy group classified by the THI average score, according to sasang constitution. We collected data with self-administered health questionnaires from 297 men and women, in 9 Korea oriental medical colleges. We diagnosed Sasang constitution using QSCC II and also estimated health degree using THI. Non-healthy group practiced much more health behaviors than healthy one, and there were significant difference in Taeeumin and Soeumin. Non-healthy group of Taeeumin, Soeumin and Soyangin all practiced much more constitutional health behaviors than healthy one, and Soeumin non-healthy and healthy one all practiced much less health behaviors than Taeeumin and Soyangin group. Non-healthy group practiced health behavior for health care and maintenance more than healthy-one, and health state was related with sasang constitution health care. Therefore, institutional and systematic environmental condition would be needed in practicing healthy behaviors for improving the quality of health, and especially developed health promotion programs according to Sasang constitution too.

Objectives : Medical qigong, originated from Mawangdui Daoyintu (馬王堆 導引圖), mainly consists of meditation, physical movements, and breathing exercises. It has been widely used to cure a variety of diseases as a regimen in Oriental medicine. This study was aimed to analyze the characteristics of medical qigong movements in the Mawangdui Daoyintu and to observe a link between each medical qigong movement and meridian system. Methods : We extracted fourteen medical qigong movements from forty-four figures in Mawangdui Daoyintu. We compared the 14 medical qigong movements of the Mawangdui Daoyintu with other types' movements of medical qigong methods. We also analyzed each movement of medical qigong in Mawangdui Daoyintu with a perspective of meridian system. Results : We found that there were common features between the medical qigong movements of the Mawangdui Daoyintu and other types' movements of medical qigong methods, including Yukjagyeol (六字訣), Paldangum (八段錦), Yukgengyeng (易筋經) and so on. From the comparison of each movement and meridian qi flow, we also found several movements related with Liver meridian and one movement related with several meridians. Conclusions : Our findings would be beneficial to understand the movements of medical qigong in the Mawangdui Daoyintu from the perspective of meridian system. This would be useful to develop a new medical qigong movements applying the meridian qi system for health and healing.

The purpose of this study was to analyze the anthocyanin contents of black soybean crude extracts derived using a countercurrent system and to compare the effects of stabilizers(${\beta}-cyclodextrin$, maltodextrin) and sugars(sucrose, maltose) on the color deterioration of the anthocyanin. When the extraction process was kept at 100$^{\circ}C$ for 120$\sim$180 min, only C3G (cyanidin-3-glucoside) was detected in the water extract. The C3G contents in the water extracts acquired at 8$^{\circ}C$, 60$^{\circ}C$, and 80$^{\circ}C$ were 2.38 ppm, 1.73 ppm, and 1.73 ppm, respectively. Sucrose and maltose retarded color deterioration of the crude pigment extract by the countercurrent method with methanol. Finally, the additions of maltodextrin or ${\beta}-cyclodextrin$ did not retard thermal color deterioration of the black soybean crude pigment extract.

최근 NAND 플래시메모리를 모바일시스템의 파일저장용 뿐 아니라 가상메모리의 스왑장치용으로 사용하려는 시도가 늘고 있다. 가상메모리의 페이지 참조는 시간지역성이 지배적이어서 LRU 및 이를 근사시킨 CLOCK 알고리즘이 널리 사용된다. 한편, NAND 플래시메모리는 읽기 연산에 비해 쓰기 연산의 비용이 높아 이를 고려한 페이지 교체 알고리즘이 필요하다. 본 논문에서는 가살메모리의 읽기/쓰기 참조 패턴을 독립적으로 분석하여 시간지역성이 강한 읽기 참조와 달리 쓰기 참조의 경우 시간지역성의 순위 역전 현상이 발생함을 발견하였다. 이에 근거하여 본 논문은 쓰기의 재참조 성향 예측을 위해 시간지역성뿐 아니라 쓰기 연산의 빈도를 함께 고려하는 페이지 교체 알고리즘을 제안한다. 새로운 알고리즘은 연산별 I/O 비용을 고려해서 메모리 공간을 읽기 연산과 쓰기 연산에 독립적으로 할당하고 참조 패턴의 변화에 적응해 할당 공간을 동적으로 변화시킨다. 알고리즘의 시간 오버헤드가 매우 적어 가상메모리 시스템에서 사용될 최적의 조건을 갖추고 있으며 파라미터 설정이 필요 없음에도 CLOCK, CAR, CFLRU 알고리즘에 비해 20-66% 정도의 I/O 성능을 향상시킴을 보였다.

Recently, NAND flash memory is being used as the swap device of virtual memory as well as the file storage of mobile systems. Since temporal locality is dominant in page references of virtual memory, LRU and its approximated CLOCK algorithms are widely used. However, cost of a write operation in flash memory is much larger than that of a read operation, and thus a page replacement algorithm should consider this factor. This paper analyzes virtual memory read/write reference patterns individually, and observes the ranking inversion problem of temporal locality in write references which is not observed in read references. With this observation, we present a new page replacement algorithm considering write frequency as well as temporal locality in estimating write reference behaviors. This new algorithm dynamically allocates memory space to read/write operations based on their reference patterns and I/O costs. Though the algorithm has no external parameter to tune, it supports optimized implementations for virtual memory systems, and also performs 20-66% better than CLOCK, CAR, and CFLRU algorithms.

Purpose: The purpose of this study was to compare the result of one-way ANOVA with that of cross-correlation time series analysis in order to evaluate physiologic responses of premature infants to human voices. Methods: Four premature infants born prior to 32 weeks gestational age were included in the study. The Gould 4000TA Recording System recorded the preterm infant's heart and respiratory rate while they were listening to a pre-recorded voice recording. Each infant listened to both male and female voices (1 min each) at each testing session. Results: The results of both one-wayANOVA and cross-correlation time series analysis using heart and respiratory rate data were not consistent in some of premature infants. A cross-correlation time series analysis revealed that the responses of premature infant to vocal stimulation occurred at a varying number of seconds after the stimulus was presented and lasted for over 20-30 sec. Conclusion: The results indicate that a time series analysis can provide more detailed information on the rapidly changing physiologic status of premature infant to the auditory stimulus. In addition, the results provide an insight into an auditory responsitivity of premature infants to a naturally occurring sound, the human voice, in the neonatal intensive care unit.

Objectives : The antidepressant effect of the subchronic administration of the methanolic extract of wild ginseng(WG) was investigated compared with that of cultivated ginseng(CG, panax ginseng) extract. Methods : To assess the antidepressant effect of the ginseng extracts, tail suspension test(TST) was executed in mice after daily administration of WG or CG extract for five consecutive days. Results : The WG extract at daily dose of 600mg/kg significantly reduced the total duration of immobility in the TST, whereas there was no significant reduction at daily dose of 300mg/kg WG and 600mg/kg CG. There were no individual differences between experimental groups in open field test (OFT) to evaluate psychostimulant effects of WG or CG extract. In the high performance liquid chromatography(HPLC) analysis of the extracts, it was found that WG included four times more ginsenoside Rg1 and Re, three times more Rf, and six times more Rb1 and Rc than CG. Conclusions : It is suggested that WG extract has stronger antidepressant effect than CG extract, which means it includes more antidepressant compounds than CG.

Objectives: Rheumatoid arthritis (RA) is a chronic autoimmune disease, principally characterized by synovial inflammation of the joints. We previously reported the effect of acupuncture for RA, but the mechanism is still unclear. Various factors such as oxidative stress and angiogenesis were involved in the pathogenesis of RA, and recently, it has also been reported that cytokines also play a major role in RA. Thus, we investigated whether acupuncture could induce any changes in the levels of cytokines including vascular endothelial growth factor (VEGF), angiogenin and epidermal growth factor (EGF) as well as erythrocyte sedimentation rate (ESR), c-reactive protein (CRP), and rheumatoid factor (RF) in the sera of RA patients. Methods: The forty three patients who met the American College of Rheumatology (ACR) criteria for RA recruited. The acupuncture group (n=21) underwent 14 sessions of partially individualized acupuncture treatment for 6 weeks, and the control group had no treatment (n=13) over the same periods. We evaluated ESR, CRP and RF. In addition, to find out the mechanism of acupuncture, we assessed the changes of the cytokine activities using protein cytokine array in the sera of the patients. Results: Acupuncture significantly decreased the levels of ESR and CRP, but RF were not changed after 6-week acupuncture treatments. Moreover, acupuncture reduced the levels of VEGF, angiogenin and EGF in the sera of the patients. Interestingly, they were related with angiogenesis, which is an important process in the pathogenesis of RA. The levels of oncostatin, interleukin(IL)-$1{\alpha}$, IL-8, leptin, monocyte chemotactic protein-1, macrophage-derived chemokine, macrophage inflammatory proteins-1, platelet-derived growth factor BB and RANTES were not changed significantly. Conclusions: The effect of acupuncture for reliving RA symptoms can be partially explained by inhibition of angiogenesis factors in the sera of the RA patients.

강원도 양구군 도솔산과 제주도에서 2종류의 미기록 귀화식물을 발견하였다. Hieracium caespitosum Dumort.는 양구군 도솔산에서 분포가 확인되었으며 조밥나물과 비교하여 두화의 수가 많고, 개화시기에도 근생엽이 달려 있는 특징이 있으며, 유럽이 원산지여서 유럽조밥나물로 신칭하였다. Trifolium incarnatum L.은 제주도 정실, 우도, 대정 가시오름 및 전라남도 보성 녹차단지 주변 등 여러 곳에서 발견되었으며 토끼풀속의 다른 식물들과는 꽃이 진홍색이고, 화서가 길게 발달하며 식물체가 직립하는 등의 특징으로 구별된다.

Two newly naturalized species were recorded from Gangwon-do and Jeju-do. Among them, numerous populations of Hieracium caespitosum (Asteraceae) were found in 2006 along the road near the military area at, Mt. Dosolsan, Yanggu-gun, Gangwon-do. The other species, Trifolium incarnatum (Fabaceae) was widespread and found at various locations including Jeongsil and Woo-do in Jeju-si, Jeju-do and Gasioreum, Daejeong-eup, Seoguipo-si, Jeju-do and Daehandawon Plantation in Hoecheon-myon, Boseong-gun, Jeonranam-do in 2008. Hieracium caespitosum was found to be distinguished from the allied species, H. umbellatum in the same genus, by a lot of capitula and a well developed cluster of basal leaves during the flowering time. Trifolium incarnatum can be distinguished from other species in the same genus by an erect form, long inflorescence and deep-red flowers.

Objectives : Acupuncture points and meridians have been usually depicted as a two dimensional drawing and verbal description. Recently, imaging and three-dimensional image processing technologies have been introduced into medical fields such as anatomy and virtual operation, for the purpose of enhanced efficiency in research and education. This study attempted an image modelling of the meridian and acupoint in the upper limb region. Methods : A vector image model of an arm was produced and medical information on the meridian and acupoint of the arm region was incorporated. Results : A 3D modelling of the acupuncture meridian and acupoint in the upper limb region was produced along with a user console to control the presentation of related information and to facilitate visualization of the 3D model images. Conclusions : A 3D modelling of the acupuncture meridian and acupoint will be an efficient platform for an education and research.

1. Introduction This study aims to survey knowledge and attitude of Sasang constitution investigators on the Sasang constitution clinical study. 2. Methods We have made up list of 24 Sasang constitution investigators who have conducted Sasang constitution clinical study before. The study has been surveyed for 20 investigators who has been experiencing clinical study bye-mail or interview. 3. Results 1) The recognition degree on clinical study for sasang constitutional investigators was relatively lower than that for non-oriental investigators. 2) Most investigators have difficulty in designing a Protocol and they thought Protocol is most important in clinical study. 3) The investigators has stressed the need of diagnosis guideline on Sasang Constitution in performing clinical study. 4. Conclusions Special course of clinical study for sasang constitutional investigators should be prepared to activate Sasang constitution clinical study. This course may set up the guideline of sasang constitution clinical study and designing protocol. Also it is urgent to develop constitution diagnosis guideline for clinical study.

Over the past few years, anthocyanin has been demonstrated to exert potentially anti-oxidative and bioavailability effects including anti-cardiovascular disease and cancer-preventive effects in humans. This study was conducted to assess the toxicity of anthocyanin extracts from black soybean seed coats via oral administration in a mice feeding test. The final anthocyanin-containing products induced signs of toxicity on mortality in the 4-week feeding test. The incidence of clinical signs and changes in body and organ weight were also not observed in all anthocyanin-treated groups as compared with the control groups. In hematology analysis, RBC indices concluding MCV, MCH, and MCHC and WBC differential counting such a NEU, LYM, MONO, EOS, and BASO evidenced no significant differences between the anthocyanin treatment and control groups. The biochemical parameters in serum analysis - ALT, AST, BUN, Crea etc.- were also not significantly altered in those groups. Absolute and relative organ weights were not increased after 4 weeks of treatment with anthocyanin extracts in mice. In conclusion, anthocyanin extracts from the black soybean has biological activity without any toxic effects, which also suggests that the consumption of soy containing anthocyanin products may be a good source for health and medical supplies.

한의학 관점의 진맥위치는 요골동맥상의 촌/관/척 세부위로 나누어진다. 거의 말초에 해당하는 근접한 부위를 세 부분으로 나누어 진맥하여 병을 진단하는데 촌/관/척 위치에 대한 해부학적 혈류역학적 근거는 부족한 상황이다. 본 논문에서는 초음파(VOLUSION730 PRO, GE Medical 미국)를 이용하여 맥진 위치의 혈관굵기, 혈관깊이 그리고 혈류 속도를 측정하고 분석해 봄으로써 맥진 위치의 구조석 차이를 이해해 보고자 한다. 또한 Body Mass Index(BMI)에 따라 혈관의 특성이 달라지는지 파악하고 한의맥진과의 상관관계를 분석해 보았다. 심혈관 질환이 없는 남자 피험자를 각각 BMI 정상인 그룹, 저체중 그룹, 과체중 그룹으로 나누어 5명씩 측정하였다. 좌, 우 손목의 맥진위치(촌, 곽, 척)에서 혈관깊이, 혈관굵기, 혈류속도를 측정하였으며 맥진기(3-D Mac, 대요메디, 한국)를 이용하여 맥파를 측정하였다. 그 결과, 비만도에 따라 혈관의 특징이 다르게 나타남을 알 수 있었으며 한의 맥의 종류 중 부맥과 치맥에 특징이 비만도와 관련 있음을 알 수 있었나 이는 피험자의 혈관 특성과 BMI 정보가 진단에 중요한 지표이며 자동 맥진 알고리즘 개발 시 반드시 고려해야 하는 사항임을 알 수 있다.

Purpose: This study was conducted to identify the status of health management and to evaluate the need for health professionals in day care centers in the South Korea. Method: Data were obtained from 360 child care providers in 16 provinces from May to August, 2007. Data was analyzed using SPSS WIN 14.0. Results: Safety education (traffic. 83.8% general safety. 71.6%) was provided more often than the other topic of education. All health related education was provided by child care providers. When minor health problems occurred, the most common management strategy was to send the child home (36.1%). During emergency conditions, majority of child care providers preferred taking the children to medical centers without giving any emergency care and 19.4% reported sending the child home without any immediate care. Child care providers recognized the need for health care professionals. Conclusion: The results of this study suggest the need for services of health professionals in day care centers to satisfy the needs and expectations for health management in these centers. As health professionals, public health nurses or pediatric nurse practitioners may play an important role in health management of children in day care centers.

l. Objectives This study aims to know the coefficient of five Sasang constitution diagnosis factors' concordance in and among Oriental Medical Clinics, which are important to diagnose Sasang constitution, 2. Methods We collected 701 subjects in Oriental Medical Clinics, who were diagnosed by experts, and they marked the priority order of Sasang constitutional factors in paper. 3. Results 1) The concordance of priority order about Sasang constitutional factors was significantly associated within Oriental Medical Clinics. 2) The concordance of priority order of Sasang constitutional factors was not significantly associated among 12 Oriental Medical Clinics, so we find out that each medical clinics has a different point of view of deciding the rank of diagnosis factors. 3) We show that the factor of Sasang constitutional drug response was the most important one to confirm Sasang constitution and factors have a different order according to clinic type and qualification of experts 4. Conclusions Sasang constitution expect has their own view in diagnosis priority order and that was different among them.

목적: 개정 도씨 술식과 승모판 고리성형을 동시에 시행한 후 심실의 형태와 기능의 초기 변화를 자기공명영상을 이용하여 평가하고자 하였다. 대상 및 방법: 총 21명의 확장성 심부전 환자를 대상으로 하여 8명에서 개정 도씨 술식을, 6명에서 승모판 고리성형을, 7명에서 두 수술을 동시에 시행하였다. 영화 자기공명영상을 이용하여 수술 전과 후에 좌심실의 형태와 기능을 평가하였다. 좌심실의 이완기말 용적과 수축기말 용적, 장축과 단축의 길이를 측정하고 이로부터 좌심실의 일회박출량, 박출률, 구형지수를 계산하여 구하였다. 이렇게 구해진 인자들을 분석하고 술식이 서로 다른 3군에서 어떻게 다른지 비교하고 두 수술을 동시에 시행할 때의 효과를 해석하였다. 결과: 자기공명영상은 수술 전 $12\;{\pm}\;15$ 일 (범위 1-58 일)과 수술 후 $38\;{\pm}\;50$ 일 (범위 7- 231 일)에 시행하였다. 두 수술을 동시에 시행한 군에서 다른 군에 비하여 수술 전 좌심실의 확장이 더 심하였고 수축력이 더 감소되어 있었다. 수술 후, 좌심실의 이완기말 용적과 수축기말 용적은 수술 형태와 관계없이 모든 환자에서 유의하게 감소하였다. 박출률은 개정 도씨 술식을 받은 환자 군에서만 유의하게 증가하였다 (25.4% to 40.7%). 구형지수는 개정 도씨 술식을 받은 환자에서는 증가하였고 승모판 고리성형을 받은 환자에서는 감소하였다 (0.65 to 0.78 vs. 0.75 to 0.65). 두 수술을 동시에 시행한 환자에서는 유의한 구형지수의 변화가 없었다. 결론: 개정 도씨 술식과 승모판 고리성형을 동시에 시행받은 확장성 심부전 환자에서 좌심실의 형태와 기능의 초기 변화는 좌심실 용적과 일회박출량의 현저한 저하이다. 승모판 고리성형에 의한 구형지수의 감소는 개정 도씨술식에 의한 구형지수의 증가에 의해 상쇄되어 좌심실의 형태는 변하지 않는다. 두 수술을 동시에 시행한 후 좌심실 박출률의 향상은 조기에 일어나지 않는다.

Purpose : We sought to determine the early change of ventricular geometry and function after concomitant surgeries of modified Dor procedure and mitral valve annuloplasty by using magnetic resonance imaging. Materials and Methods : We enrolled 21 patients with dilated heart failure who underwent modified Dor procedure (n=8), mitral valve annuloplasty (n=6), or both surgeries (n=7). Cine MRI was used to assess left ventricular dimensions and function before and after surgery. We measured the left ventricular end-diastolic and end-systolic volumes and the dimensions of the left ventricular long-axis and short-axis. Left ventricular stroke volume, ejection fraction, and sphericity index were calculated from these measurements. These parameters were analyzed and compared between three different surgery groups to explain the combined effect of the concomitant surgeries. Results : MRI was performed within average $12\;{\pm}\;15$ days (range 1-58 days) before and $38\;{\pm}\;50$ days (range 7- 231 days) after the surgery. The patients who underwent concomitant surgeries had more profound enlargement of left ventricle and decreased contractility prior to surgery than those in the patients who underwent single surgical procedure. Left ventricular end-diastolic volume and endsystolic volume significantly decreased in all patients regardless of surgery type after surgery. Ejection fraction significantly increased only in the patients who got modified Dor procedure without mitral valve annuloplasty (25.4% to 40.7%). Sphericity index increased in patients with modified Dor procedure but decreased in patients with mitral valve annuloplasty (0.65 to 0.78 vs. 0.75 to 0.65). In the patients who underwent concomitant surgeries showed no significant change in sphericity index after surgery. Conclusion : The early change of the left ventricular geometry and function after the concomitant surgeries with modified Dor procedure and mitral valve annuloplasty in patients with dilated heart failure includes a marked reduction in left ventricular volume and in stroke volume. The shape of the left ventricle does not change because the effect of sphericity index decrease from mitral valve annuloplasty is counteracted by the effect of sphericity index increase from modified Dor procedure. Improvement of left ventricular ejection fraction is not the early change after the concomitant surgeries.