The biotechnology industry demands new and high-performance online measurements to identify important process variables. The ultrasonic measurement in combination with mathematical models provides online control of bioprocesses. Characteristically, yeast cultivations show different process phases such as glucose, ethanol and acetate consumption which can be identified via ultrasonic velocity measurements. In addition, a prediction was carried out with measured and simulated data and thus, the process variables were calculated. Because the ultrasonic signals depends on several unspecific variables, this research uses theoretic and chemometric models to correlate the online measurement of the ultrasonic velocity with the offline measurements of the process variables. The prediction of different process variables were performed by so-called software sensors, which are based on multilinear regression, principal component analysis, extended Kalman filter and neural networks. The simulated values and the measurements of ultrasonic velocity were used for the evaluation as well as the prediction of ethanol concentration.
키워드
fermentation processescehmometric modelultrasonic sensor system
저자
Young-Lok Cha [ Institute of industrial biotechnology, Inha university ]
한국생물공학회 [The Korean Society for Biotechnology and Bioengineering]
설립연도
1984
분야
공학>생물공학
소개
이 법인은 생물 공학의 발전과 보급에 이바지하고, 회원 상호 간의 연구 협력과 친목을 도모함을 목적으로 한다
1. 생물공학 분야의 발전을 위한 연구 협력
2. 생물공학의 실용화를 촉진시키기 위한 산학 협동
3. 학술연구 발표회, 강연회, 연수회 등 학술활동의 개최
4. 국,영문 학술지,소식지,학술회의 Proceedings 및 학술도서의 발간
5. 생물공학 발전을 위한 정책 건의
6. 기타 국제 교류 등 본 학회의 목적 달성을 위한 제반 활동