Le Quang To, Sun-Yup Shim, Keun-Hwa park, Se-Kwon Kim
언어
영어(ENG)
URL
https://www.earticle.net/Article/A99649
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원문정보
초록
영어
In an attempt to search for new therapeutic materials, the anti-allergic effect of Ecklonia cava (E. cava) was observed as a part of a screening study carried out to identify biologically active antiallergic medicinal sources from number of marine algal species. In this study, we investigated the inhibitory effect of E. cava extract on the expression of the FcεRI in human basophilic KU812F cells. Flow cytometric analysis revealed that E. cava extract exerts a concentration-dependent reduction in expression of FcεRI on cell surface. Latter experiments further revealed that this extract is capable of reducing the binding between human myeloma IgE, or mite allergen-specific IgE, and cell surface FcεRI. Interestingly, E. cava extract reduced total cellular FcεRI α chain mRNA expression analyzed using RT-PCR. Moreover, data obtained using fluorescence spectrophotometer revealed that E. cava extract also inhibits FcεRI-mediated histamine release in aconcentration-dependent manner. These results suggested that E. cava extract negatively regulates FcεRI expression and basophil degranulation and could be a potential candidate to carry out further studies concerning about protection from allergic diseases.
키워드
Ecklonia cavaFcεRIIgEhistamine
저자
Le Quang To [ Department of Chemistry, Pukyong National University ]
Sun-Yup Shim [ Marine Bioprocess Research Center, Pukyong National University ]
Keun-Hwa park [ Department of Chemistry, Pukyong National University ]
Se-Kwon Kim [ Marine Bioprocess Research Center, Pukyong National University, Republic of Korea, Department of Chemistry, Pukyong National University ]
한국생물공학회 [The Korean Society for Biotechnology and Bioengineering]
설립연도
1984
분야
공학>생물공학
소개
이 법인은 생물 공학의 발전과 보급에 이바지하고, 회원 상호 간의 연구 협력과 친목을 도모함을 목적으로 한다
1. 생물공학 분야의 발전을 위한 연구 협력
2. 생물공학의 실용화를 촉진시키기 위한 산학 협동
3. 학술연구 발표회, 강연회, 연수회 등 학술활동의 개최
4. 국,영문 학술지,소식지,학술회의 Proceedings 및 학술도서의 발간
5. 생물공학 발전을 위한 정책 건의
6. 기타 국제 교류 등 본 학회의 목적 달성을 위한 제반 활동