Clostridium acetobutylicum is an attention-grabbing bacterium in that it produces several solvents, especially butan-1-ol. We reconstructed a genome-scale metabolic network of C. acetobutylicum ATCC 824 which comprises 502 reactions and 479 metabolites. Then, we carried out flux balance analysis using both linear and non-linear approach which is a modification of previous studies.1,2) Here, we present metabolic features and feasibilities of C. acetobutylicum, and hypothetical annotations derived during the reconstruction of the network. [This work was supported by the Korea–Australia Collaborative Research Project on the Development of Sucrose-Based Bioprocess Platform (N02071165) from the Korean Ministry of Knowledge Economy. Further support by LG Chem Chair Professorship and Microsoft are appreciated.]
저자
Joungmin Lee [ Metabolic and Biomolecular Engineering National Research Laboratory, Department of Chemical & Biomolecular Engineering (BK21 Program), BioProcess Engineering Research Center, Center for Systems and Synthetic Biotechnology and Institute for the BioCentury, KAIST ]
Hongseok Yun [ Metabolic and Biomolecular Engineering National Research Laboratory, Department of Chemical & Biomolecular Engineering (BK21 Program), BioProcess Engineering Research Center, Center for Systems and Synthetic Biotechnology and Institute for the BioCentury, KAIST ]
Sang Yup Lee [ Metabolic and Biomolecular Engineering National Research Laboratory, Department of Chemical & Biomolecular Engineering (BK21 Program), BioProcess Engineering Research Center, Center for Systems and Synthetic Biotechnology and Institute for the BioCentury, KAIST, Department of Bio and Brain Engineering, Department of Biological Sciences and Bioinformatics Research Center, KAIST ]
한국생물공학회 [The Korean Society for Biotechnology and Bioengineering]
설립연도
1984
분야
공학>생물공학
소개
이 법인은 생물 공학의 발전과 보급에 이바지하고, 회원 상호 간의 연구 협력과 친목을 도모함을 목적으로 한다
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