Earticle

초록

영어

Ferritin is a major iron storage protein that is widely distributed in animal and plant tissues, and consists of 24 subunits to form a hollow shell with an outer diameter of 12 nm and an inner diameter of 8 nm. The iron core naturally existing inside the ferritin was found to be readily extracted and replaced with various materials such as metals, metal oxides, and semiconductors. Thus, ferritins can act as a nano-scale template, a biocompatible cage, and a separator between the nanoparticles. In the present study, ferritins were chemically reconstituted with cobalt and manganese oxyhydroxides. The formation of Co(O)OH within the apoferritin interior was conducted in MOPS and HEPES buffers at pH 8.3-8.5 using hydrogen peroxide as the oxidant and Mn(O)OH-reconstituted ferritin was prepared in AMPSO buffer at pH 8.9 using
air as the oxidant. The synthesis of Co(O)OH and Mn(O)OH in the cavity of apoferritin was monitored by UV-visible spectrophotometry for ranging from 300 to 800 nm. It is expected that ferritins reconstituted with cobalt and manganese oxyhydroxides will have a variety of applications due to their chemical reactivity and electrochemical activity.

저자

• Keehoon Won [ Department of Chemical and Biochemical Engineering, Dongguk University ]
• Hae Sook Jung [ Department of Chemical and Biochemical Engineering, Dongguk University ]
• Ji Hyeon Kim [ Department of Chemical and Bio Engineering, Kyungwon University ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국생물공학회 학술대회

• 간기

  반년간

• 수록기간

  1985~2013

• 십진분류

  KDC 476 DDC 576