Thermo-sensitive hydrogels are commonly used in many biomedical and pharmaceutical applications, including tissue engineering and drug delivery systems. Due to their sensitivity to thermal stimulus, they have a great potential in site-specific controlled drug-delivery systems. A new class of injectable and bioabsorbable supramolecular hydrogels, which are formed from poly(ethylene oxide) (PEO) and α-cyclodextrin (α-CD), have been investigated for controlled drug delivery. In this study, we examined the release profiles of several poorly water-soluble drugs from these new biodegradable hydrogels. Physically crosslinked hydrogels were prepared from mixed aqueous solutions of PEO and α-CD using a temperature-controlled gelation technique at various concentrations of both compounds. The drug release profiles of several drugs from hydrogels were determined in vitro via dialysis using high-performance liquid chromatography.
저자
Ji-Eun Lee [ Department of Chemical and Biochemical Engineering, The University of Suwon ]
In-Il Jung [ Department of Chemical Engineering, Yonsei University, Korea ]
Gio-Bin Lim [ Department of Chemical and Biochemical Engineering, The University of Suwon ]
Jong-Hoon Ryu [ Department of Chemical and Biochemical Engineering, The University of Suwon ]
한국생물공학회 [The Korean Society for Biotechnology and Bioengineering]
설립연도
1984
분야
공학>생물공학
소개
이 법인은 생물 공학의 발전과 보급에 이바지하고, 회원 상호 간의 연구 협력과 친목을 도모함을 목적으로 한다
1. 생물공학 분야의 발전을 위한 연구 협력
2. 생물공학의 실용화를 촉진시키기 위한 산학 협동
3. 학술연구 발표회, 강연회, 연수회 등 학술활동의 개최
4. 국,영문 학술지,소식지,학술회의 Proceedings 및 학술도서의 발간
5. 생물공학 발전을 위한 정책 건의
6. 기타 국제 교류 등 본 학회의 목적 달성을 위한 제반 활동