The purpose of this study was to develop nanoparticle which have a specificity at tumor site and multidrug resistant cancer cells. A cationic polymer/vitamin conjugated for preparation of the nanoparticles. The cationic polymer has cytotoxicity, but the nanoparticle from the conjugate slightly reduced the toxicity. However, there are still remained a toxicity. For this reason, the nanoparticle was covered with biocompatible polysaccharide(BP) which can be easily degraded by an enzyme from tumor site.1) And the vitamin has a hydrophobicity, so the nanoparticle can loaded with hydrophbic anticancer drug. Drug loaded nanoparticle was expected that MDR effect should be reduced, and the the cationic polymer increase a anticancer effect.2) The cytotoxicity of the nanoparticle measured by MTT assay depended on the enzyme concentration. The interaction between the nanoparticle and cancer cells was observed by confocal microscopy as a function of BP concentration. The result indicated that BP can enhance the specificity of tumor site due to inhibit the internalization of the nanoparticle in the normal tissue.
저자
Eun Ae Jo [ Department of Biotechnology, The Catholic University of Korea ]
Kun Na [ Department of Biotechnology, The Catholic University of Korea ]
한국생물공학회 [The Korean Society for Biotechnology and Bioengineering]
설립연도
1984
분야
공학>생물공학
소개
이 법인은 생물 공학의 발전과 보급에 이바지하고, 회원 상호 간의 연구 협력과 친목을 도모함을 목적으로 한다
1. 생물공학 분야의 발전을 위한 연구 협력
2. 생물공학의 실용화를 촉진시키기 위한 산학 협동
3. 학술연구 발표회, 강연회, 연수회 등 학술활동의 개최
4. 국,영문 학술지,소식지,학술회의 Proceedings 및 학술도서의 발간
5. 생물공학 발전을 위한 정책 건의
6. 기타 국제 교류 등 본 학회의 목적 달성을 위한 제반 활동