Earticle

초록

영어

Drug-loaded biodegradable polymeric nano- and microparticles are of great interest in the development of controlled-release devices for therapeutic applications. Recently, some studies on the incorporation of cyclodextrins (CDs) and their derivatives into polymeric drug delivery carriers such as microspheres, nanospheres and polymeric films have been conducted. In the present study, we will propose a novel method for producing poly(D,L-lactic-co-glycolic acid)
(D,L-PLGA) nano- and microparticles through inclusion complexation (IC) with CD derivatives using an aerosol solvent extraction system (ASES) process with supercritical carbon dioxide (SCCO2) as an antisolvent. Various D,L-PLGA/CD IC particles of different molar ratios were produced at various temperatures and pressures by the ASES process. Ultrafine IC particles were prepared satisfactorily in molar ratios of D,L-PLGA monomer to CD ranging from 10:1 to
100:1. These results have shown that particle production of polymers with low glass transition temperatures through inclusion complexation with CDs and their derivatives using SCCO2 is a promising method, especially for controlled-release formulations of poorly water-soluble drugs.

저자

• In-Il Jung [ Department of Chemical Engineering, Yonsei University, Department of Chemical and Biochemical Engineering, The University of Suwon ]
• Seungjoo Haam [ Department of Chemical Engineering, Yonsei University ]
• Gio-Bin Lim [ Department of Chemical and Biochemical Engineering, The University of Suwon ]
• Jong-Hoon Ryu [ Department of Chemical and Biochemical Engineering, The University of Suwon, Korea ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국생물공학회 학술대회

• 간기

  반년간

• 수록기간

  1985~2013

• 십진분류

  KDC 476 DDC 576