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Effects of Fermented Rice Bran Extracts on Aging and Inflammation of Skin Keratinocytes
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- 발행기관
- 한국생물공학회 바로가기
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- 간행물
- 한국생물공학회 학술대회 바로가기
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- 통권
- 2008 추계학술대회 및 국제심포지움 (2008.10)바로가기
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- 페이지
- pp.150-150
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- 저자
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- 언어
- 영어(ENG)
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- URL
- https://www.earticle.net/Article/A99264
※ 원문제공기관과의 협약기간이 종료되어 열람이 제한될 수 있습니다.
원문정보
초록
- 영어
- Background/purpose: Recently, many reports have shown the potential of new materials as cosmetic ingredients. These have demonstrated beneficial effects on skin recovery and wound healing. In this study, we investigated the effects of fermented rice bran extracts on damaged skin cells. In this study, we have focused on the possible effects of rice bran extracts on UV-irradiated normal human skin keratinocytes.
Method: Normal human skin was aseptically isolated from a circumcised neonatal foreskin. And epidermal layers were mechanically stripped and keratinocytes were isolated form the epidermis. The human keratinocytes were seeded at a density of 1ⅹ105 cells/well in 6 well plates and then irradiated after 1 day. Prior to irradiation, cells were washed with PBS and irradiation was performed through a thin film of PBS via exposure to a 20 mJ/㎠ with UV B of 312 nm dose, as measured with an SX-312 research radiometer. Human normal keratinocytes were UV irradiated and treated 0.1%, 0.5% and 1% of FRBE and 25nM ascorbic acid.
Results: Cell viability following UV irradiation was significantly higher in the groups treated with FRBE at doses of 0.1, 0.5, and 1.0%, in comparison to the control group with UV irradiation only. And UV-irradiated cells demonstrated decreased levels of laminin as well as increased cytokine production (MMP-1, MMP-2), relative to nonirradiated controls.
Conclusion: We found that treatment of these UV-irradiated keratinocyte with fermented rice bran extracts increased laminin protein levels and decreased cytokine production. In conclusion, the data obtained in this work suggest that fermented rice bran extract has potential as a medical treatment following UV exposure.
저자
간행물 정보
발행기관
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- 발행기관명
- 한국생물공학회 [The Korean Society for Biotechnology and Bioengineering]
- 설립연도
- 1984
- 분야
- 공학>생물공학
- 소개
- 이 법인은 생물 공학의 발전과 보급에 이바지하고, 회원 상호 간의 연구 협력과 친목을 도모함을 목적으로 한다 1. 생물공학 분야의 발전을 위한 연구 협력 2. 생물공학의 실용화를 촉진시키기 위한 산학 협동 3. 학술연구 발표회, 강연회, 연수회 등 학술활동의 개최 4. 국,영문 학술지,소식지,학술회의 Proceedings 및 학술도서의 발간 5. 생물공학 발전을 위한 정책 건의 6. 기타 국제 교류 등 본 학회의 목적 달성을 위한 제반 활동
간행물
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- 간행물명
- 한국생물공학회 학술대회
- 간기
- 반년간
- 수록기간
- 1985~2013
- 십진분류
- KDC 476 DDC 576
이 권호 내 다른 논문 / 한국생물공학회 학술대회 2008 추계학술대회 및 국제심포지움
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