PDMS is well known as one of the best biomaterials due to its stability and biocompatibility. To apply PDMS to cell based biochip, proper surface modifcations such as collagen and gelatin are required to adhere cell on its surface. In this study, the nano-scaled irregular patterns on the PDMS surface was developed to fabricate cell based biochip without chemical and biological treatment. PDMS surface was modified by formation of irregular nano patterns using surface deformation technology. Hydrophobicity of modified PDMS surface was sustained with basic PDMS surface. To measure adhesion properties and viability of Human Mammary Epithelial Cells(HMEC) on the surface proposed here, AFM and confocal microscopy were utilized and their results were compared with that from commercial culture dish. It implies modified PDMS surface can be directly applied to cell based biochip without even any reagents. Acknowledgments: This work was supported by the Korea Science and Engineering Foundation (KOSEF) grant funded by the Korea government (MOST) (No. M10755160002-07N5516-00210).
저자
Sung Hee Chung [ Department of Chemical and Biomolecular Engineering ]
Junhong Min [ College of Bionanotechnology, Kyungwon University ]
한국생물공학회 [The Korean Society for Biotechnology and Bioengineering]
설립연도
1984
분야
공학>생물공학
소개
이 법인은 생물 공학의 발전과 보급에 이바지하고, 회원 상호 간의 연구 협력과 친목을 도모함을 목적으로 한다
1. 생물공학 분야의 발전을 위한 연구 협력
2. 생물공학의 실용화를 촉진시키기 위한 산학 협동
3. 학술연구 발표회, 강연회, 연수회 등 학술활동의 개최
4. 국,영문 학술지,소식지,학술회의 Proceedings 및 학술도서의 발간
5. 생물공학 발전을 위한 정책 건의
6. 기타 국제 교류 등 본 학회의 목적 달성을 위한 제반 활동