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Effect of Camellia japonica oil on human type I procollagen production and skin barrier function

첫 페이지 보기
  • 발행기관
    한국생물공학회 바로가기
  • 간행물
    한국생물공학회 학술대회 바로가기
  • 통권
    2007 춘계학술대회 및 국제심포지움 (2007.04)바로가기
  • 페이지
    pp.18-18
  • 저자
    Eunsun Jung, Jongsung Lee, Jihoon Baek, Kwangsun Jung, Jiyoung Lee, Sungran Huh, Saebom Kim, Jaesook Koh, Deokhoon Park
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A99096

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원문정보

초록

영어
Type I collagen is the primary component of the skin dermis. Both the quantity and quality of extracellular collagen are primarily related to skin ageing. In this study, we investigated the possibility that Camellia japonica oil (CJ oil) may be introduced as an anit-wrinkle agent. As a first step to this end, human COL1A2 promoter luciferase assay was performed in human dermal fibroblast cells. CJ oil was determined to activate human COL1A2 promoter in a concentration-dependent manner. In a consistent with this result, while MMP (matrix metalloproteinase)-1 activity was inhibited by CJ oil, human type I procollagen synthesis was also induced by CJ oil. These results suggest the possibility that CJ oil may be involved in the skin ageing. For the evaluation of CJ oil’s safety and efficiency on human skin, human skin primary irritation test and trans-epidermal water loss (TEWL) were performed. Transepidermal water loss (TEWL) was measured before treatment then, 1 h and 2 h after treatment; the forearm site was selected to measure TEWL. Also, a human skin primary irritation test was performed on the normal skin (upper back) in 30 volunteers to see if a certain material included in CJ oil has irritation or sensitization potential. In these assays, CJ oil reduced trans-epidermal water loss (TEWL) and did not induce any adverse reactions. Therefore, based on these results, we suggest the possibility that CJ oil may be considered as possible wrinkle-reducing candidates for topical application.

저자

  • Eunsun Jung [ Biospectrum Life Science Institute, Eunsun J. and Jongsung, L. contributed equally to this work ]
  • Jongsung Lee [ Biospectrum Life Science Institute, Eunsun J. and Jongsung, L. contributed equally to this work ]
  • Jihoon Baek [ Dermpro Skin Research Center ]
  • Kwangsun Jung [ Biospectrum Life Science Institute ]
  • Jiyoung Lee [ Biospectrum Life Science Institute ]
  • Sungran Huh [ Biospectrum Life Science Institute ]
  • Saebom Kim [ Biospectrum Life Science Institute ]
  • Jaesook Koh [ Dermpro Skin Research Center ]
  • Deokhoon Park [ Biospectrum Life Science Institute ]

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    한국생물공학회 [The Korean Society for Biotechnology and Bioengineering]
  • 설립연도
    1984
  • 분야
    공학>생물공학
  • 소개
    이 법인은 생물 공학의 발전과 보급에 이바지하고, 회원 상호 간의 연구 협력과 친목을 도모함을 목적으로 한다 1. 생물공학 분야의 발전을 위한 연구 협력 2. 생물공학의 실용화를 촉진시키기 위한 산학 협동 3. 학술연구 발표회, 강연회, 연수회 등 학술활동의 개최 4. 국,영문 학술지,소식지,학술회의 Proceedings 및 학술도서의 발간 5. 생물공학 발전을 위한 정책 건의 6. 기타 국제 교류 등 본 학회의 목적 달성을 위한 제반 활동

간행물

  • 간행물명
    한국생물공학회 학술대회
  • 간기
    반년간
  • 수록기간
    1985~2013
  • 십진분류
    KDC 476 DDC 576

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    피인용수 : 0(자료제공 : 네이버학술정보)

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