Earticle

초록

영어

In the cascade of neurotransmission, neuronal SNARE proteins play a central role. Neuronal SNARE proteins mediate membrane fusion between presynaptic membrane and synaptic vesicle. By the result of synaptic membrane fusion, a fusion pore is made through which neurotransmitters are released. SNARE complex is thought to generate fundamental force that is required for the membrane fusion. As is well-known, a few types of botulinum neurotoxin have been developed and commercialized for the purpose of cosmetic and therapeutic uses. For example, Botox, a popular cosmetic agent, is to cleave SNARE proteins disabling neurotransmission. When neurotransmission is disabled, muscle cannot contract or relax. That is the way Botox works. So, it is that SNARE folding modulator may act like Botox by inhibiting the folding of SNARE complex not by cleaving the SNARE proteins. In the present study, we could draw some candidate SNARE folding modulators from phenolic compounds. A few compounds inhibited SNARE complex formation. As expected, the phenolic compounds inhibited membrane fusion and neurotransmitter release from PC12 cells, too. Probably, the phenolic compounds may play a role as an effective anti-wrinkle agent.

저자

• Chang Hwa Jung [ Department of Genetic Engineering, Sungkyunkwan University ]
• Yoo Soo Yang [ Department of Genetic Engineering, Sungkyunkwan University ]
• Jun Seub Kim [ Department of Genetic Engineering, Sungkyunkwan University ]
• Dae Hyuk Kweon [ Department of Genetic Engineering, Sungkyunkwan University ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국생물공학회 학술대회

• 간기

  반년간

• 수록기간

  1985~2013

• 십진분류

  KDC 476 DDC 576