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Nanoassemblies for Anticancer Drug and Protein Delivery
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- 발행기관
- 한국생물공학회 바로가기
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- 간행물
- 한국생물공학회 학술대회 바로가기
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- 통권
- 2008 추계학술대회 및 국제심포지움 (2008.10)바로가기
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- 페이지
- pp.16-16
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- 저자
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- 언어
- 영어(ENG)
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- URL
- https://www.earticle.net/Article/A99055
※ 원문제공기관과의 협약기간이 종료되어 열람이 제한될 수 있습니다.
원문정보
초록
- 영어
- Recent progress in polymer nanotechnology has been directed to the application of biodegradable nanoassemblies based on natural proteins and polysaccharides as drug delivery systems, due to their biodegradation, sustained-release properties, sub-cellular size and stability. Recombinant human gelatin-based nanoparticles were prepared by a simple coacervation method, which are suitable for the hydrophilic protein drug delivery. In addition,
a hydrophobically modified glycol chitosan (HGC) was prepared by a conjugation of glycol chitosan with 5β-cholanic acid. In aqueous phases, the HGC conjugates formed nanoparticles. Their hydrophobic cores were surrounded with a hydrophilic outer domain. The inner domain can serve as a nano-reservoir for a variety of hydrophobic anticancer drugs. The characteristics
of nanoparticles were investigated by various physicochemical techniques to examine the possibility as drug carriers. Although recent progress in biotechnology enables production of various protein drugs for therapeutic purposes, several challenges still remain, including enzymatic susceptibility, stability during storage, and efficacy after administration into the body.
Promising approaches to overcome these limitations is to use nanoparticular drug delivery systems or in situ forming gels to achieve the controlled protein drug release, systemically or locally, over a long period of time. The controlled local drug delivery is aimed to facilitate high site-specific concentrations of therapeutic agents with prolonged retention at lower doses with reduced systemic toxicity. In situ gels can solve the problems associated with most widely used biodegradable microsphere formulations, such as the drug loss caused by low encapsulation efficiencies of microspheres, the use of harsh organic solvent and manufacturing costs increases by several processes.
Definitely, the parenteral delivery including in-situ polymer gels is currently most demanding and suitable for the successful development of recombinant therapeutic proteins by stabilizing and controlling the release rate of sensitive proteins.
저자
간행물 정보
발행기관
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- 발행기관명
- 한국생물공학회 [The Korean Society for Biotechnology and Bioengineering]
- 설립연도
- 1984
- 분야
- 공학>생물공학
- 소개
- 이 법인은 생물 공학의 발전과 보급에 이바지하고, 회원 상호 간의 연구 협력과 친목을 도모함을 목적으로 한다 1. 생물공학 분야의 발전을 위한 연구 협력 2. 생물공학의 실용화를 촉진시키기 위한 산학 협동 3. 학술연구 발표회, 강연회, 연수회 등 학술활동의 개최 4. 국,영문 학술지,소식지,학술회의 Proceedings 및 학술도서의 발간 5. 생물공학 발전을 위한 정책 건의 6. 기타 국제 교류 등 본 학회의 목적 달성을 위한 제반 활동
간행물
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- 간행물명
- 한국생물공학회 학술대회
- 간기
- 반년간
- 수록기간
- 1985~2013
- 십진분류
- KDC 476 DDC 576
이 권호 내 다른 논문 / 한국생물공학회 학술대회 2008 추계학술대회 및 국제심포지움
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