Earticle

초록

영어

Lymphatic drug delivery is an important research field because the lymphatic system plays an important role as a transferal route of various diseases. The major purposes of this study is to prepare dextran acetate (DxA) nanoparticles for cyclosporin A (CSA) delivery and to evaluate
delivery properties of the nanoparticles into lymphatic sites with radioscintigraphy. Dextran was chemically acetylated and CsA-loaded DxA nanoparticles were prepared by a dialysis method. Tc-99m was radiolabeled to the nanoparticles for tracing of delivery routes. Morphology of the
CsA-loaded DxA nanoparticles observed by SEM and TEM was spherical in shape and the particle mean size was 200 nm. Radiolabeling efficiency of the nanoparticles determined by thin layer chromatography was 95%. In vivo animal study, it was rapid injection site clearly and low distal lymph node accumulation showed that the CsA-loaded DxA nanoparticles could be
delivered to the lymphatic system. The biodistribution of 99mTc-loaded CsA-Dextran Acetate Nanoparticles in mice was investigated by subcutaneous injection into the foot pad. The biodistributions of 99mTc-HSA and 99mTc-loaded CsA-Dextran Acetate Nanoparticles were also investigated for comparison. Dynamic whole-body images were obtained for 30 min after
subcutaneous injection into the rats foot pads. Therefore in vivo study proved that CsA-loaded DxA nanoparticles showed enhanced accumulation of drug efficacy in the lymph node.

저자

• Jin Kim [ Department of Advanced Chemicals,Chonnam National University ]
• Kyong-Hwan Chung [ Center for Functional Nano Fine Chemicals, Chonnam National University ]
• Ki-Young Lee [ Faculty of Applied Chemical Engineering, Chonnam National University ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국생물공학회 학술대회

• 간기

  반년간

• 수록기간

  1985~2013

• 십진분류

  KDC 476 DDC 576