Alzheimer's disease(AD) is a neurodegenerative dementia characterized by memory loss and cognitive impairment. The sensitive and selective detection method is required in order to early definitive diagnosis of AD. Beta-amyloid is very attractive as a potential biomarker because of its natural association with the amyloid plaque. This study was based on measuring the beta-amyloid protein concentration and Scanning Tunneling Microscopy(STM) was studied for ultrasensitive feature measurement. STM is versatile technique to apply biosensor for beta-amyloid, because STM provides a topography and current of the atomic arrangement of a biosurface using gold nanoparticle. Gold nanoparticle immobilized on the surface has different electrical properties, it can be analyzed within nanoscale using STM. In this study, gold(Au) nanoparticle-antibody conjugate was applied and STM current change of biosurface can be utilized as quantitative analysis. Experimental results show that the proposed measurement technique can be applied to the nanoscale investigation with respect to a variety of biosensor for diagnosis, drug discovery and on-site monitoring of Alzheimer's Disease. Acknowledgments : This research was supported by the Nano/Bio science & Technology Program (M10536090001-05N3609-00110) of the Ministry of Science and Technology (MOST), by the Korea goverment (MOST) (2006-05374), and by the Korea Research Foundation Grant funded by the Korean Government(MOEHRD) (KRF-2006-005-J02301)
저자
Da-Yeon Kang [ Department of Chemical & Biomolecular Engineering, Sogang University ]
Jin-Ho Lee [ Department of Chemical & Biomolecular Engineering, Sogang University ]
Cheol-Heon Yea [ Department of Chemical & Biomolecular Engineering, Sogang University ]
Byung-Keun Oh [ Department of Chemical & Biomolecular Engineering, Sogang University, Interdisciplinary Program of Integrated Biotechnology, Sogang University ]
Jeong-Woo Choi [ Department of Chemical & Biomolecular Engineering, Sogang University, Interdisciplinary Program of Integrated Biotechnology, Sogang University ]
한국생물공학회 [The Korean Society for Biotechnology and Bioengineering]
설립연도
1984
분야
공학>생물공학
소개
이 법인은 생물 공학의 발전과 보급에 이바지하고, 회원 상호 간의 연구 협력과 친목을 도모함을 목적으로 한다
1. 생물공학 분야의 발전을 위한 연구 협력
2. 생물공학의 실용화를 촉진시키기 위한 산학 협동
3. 학술연구 발표회, 강연회, 연수회 등 학술활동의 개최
4. 국,영문 학술지,소식지,학술회의 Proceedings 및 학술도서의 발간
5. 생물공학 발전을 위한 정책 건의
6. 기타 국제 교류 등 본 학회의 목적 달성을 위한 제반 활동