Earticle

초록

영어

Recently, hydroxylated products of daidzein and genistein are a growing scientific interest for their health-related qualities. Hydroxylated products have potent antioxidant properties that contribute to their cholesterol lowering effect, cardiovascular protection, antitumor effect, and anticarcinogenic properties Doenjang (Fermented Soybean paste) is a unique Korean traditional food fermented by many useful microorganisms including fungi and bacilli. Isoflavones have biological effects due to their potential beneficial properties for human health. We have been interested in a microbial metabolite of isoflavone in highly aged Doenjang. Recently, we isolated three o-dihydroxyisoflavones (ODI), 6-hydroxydaidzein (6-OHD), 8-hydroxydaidzein (8-OHD) and
3`-hydroxydaidzein (3`-OHD), and evaluated some biological activity. ODIs show predominant effect on antioxidation activity and melanogenesis inhibition. And we studied the formation of modified isoflavones from daidzein and genistein by the genus Streptomyces. Streptomyces avermitilis MA4680 could hydroxylate at ortho-specific position and methoxylate subsequently.
The great potentiality in applications such as the production of hydroxylated isoflavones and drug metabolites or bioremediation will be motivated for researchers to find new paradigm.

저자

• Changhyun Roh [ School of Chemical and Biological Engineering, Seoul National University, Seoul, 151-744, Korea. Institute of Molecular Biology and Genetics, 105-103, Seoul, Korea. ]
• Kwon-Young Choi [ School of Chemical and Biological Engineering, Seoul National University, Seoul, 151-744, Korea. Institute of Molecular Biology and Genetics, 105-103, Seoul, Korea. ]
• Bishnu Prasad Pandey [ School of Chemical and Biological Engineering, Seoul National University, Seoul, 151-744, Korea. Institute of Molecular Biology and Genetics, 105-103, Seoul, Korea. ]
• Min-Ho Cha [ School of Chemical and Biological Engineering, Seoul National University, Seoul, 151-744, Korea. Institute of Molecular Biology and Genetics, 105-103, Seoul, Korea ]
• Su-Hyun Seo [ School of Chemical and Biological Engineering, Seoul National University, Seoul, 151-744, Korea. Institute of Molecular Biology and Genetics, 105-103, Seoul, Korea ]
• June-Hyung Kim [ School of Chemical and Biological Engineering, Seoul National University, Seoul, 151-744, Korea. Institute of Molecular Biology and Genetics, 105-103, Seoul, Korea ]
• Jun-Seong Park [ Skin Research Institute, AMOREPACIFIC R&D Center ]
• Hye Yoon Park [ Skin Research Institute, AMOREPACIFIC R&D Center ]
• Ho Sik Rho [ Skin Research Institute, AMOREPACIFIC R&D Center ]
• Duck Hee Kim [ Skin Research Institute, AMOREPACIFIC R&D Center ]
• Ih Seop Chang [ Skin Research Institute, AMOREPACIFIC R&D Center ]
• Byung-Gee Kim [ School of Chemical and Biological Engineering, Seoul National University, Seoul, 151-744, Korea. Institute of Molecular Biology and Genetics, 105-103, Seoul, Korea. ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국생물공학회 학술대회

• 간기

  반년간

• 수록기간

  1985~2013

• 십진분류

  KDC 476 DDC 576