Genomics” based on the recent developments in high-throughput technologies such as automated DNA sequencer and DNA microarray opens the area of systemic approaches in bioscience and biotechnology (systems biology). Especially, almost inaccessible biological features are expected to be uncovered with these genomic analysis tools and eventually huge progress in chemical, pharmaceutical, and healthcare industries would be achieved. These methods are, however, not quite applicable to wide range of biological systems due to incorrect hybridization, insufficient resolution, image corruption (DNA microarray), and relatively low-throughput (automated DNA microarray). In order to avoid the significant errors caused by incorrect hybridization, we developed a novel DNA analysis method independent from hybridization using single-strand conformation polymorphism based on capillary electrophoresis (CE-SSCP). Since a number of genes can be separated in CE based on the folding changes dependent on sequences with high reproducibility, it is applicable to mRNA quantification, expression profiling, and mutation analysis with high precision and sensitivity.
저자
Ki Won Shin [ I-Bio Program ]
Young Seoub Park [ Department of Chemical Engineering, POSTECH ]
Gyoo Yeol Jung [ I-Bio Program and Department of Chemical Engineering, POSTECH ]
한국생물공학회 [The Korean Society for Biotechnology and Bioengineering]
설립연도
1984
분야
공학>생물공학
소개
이 법인은 생물 공학의 발전과 보급에 이바지하고, 회원 상호 간의 연구 협력과 친목을 도모함을 목적으로 한다
1. 생물공학 분야의 발전을 위한 연구 협력
2. 생물공학의 실용화를 촉진시키기 위한 산학 협동
3. 학술연구 발표회, 강연회, 연수회 등 학술활동의 개최
4. 국,영문 학술지,소식지,학술회의 Proceedings 및 학술도서의 발간
5. 생물공학 발전을 위한 정책 건의
6. 기타 국제 교류 등 본 학회의 목적 달성을 위한 제반 활동