Earticle

초록

영어

Propionibacterium acnes is the predominant organism in sebaceous regions of the skinand is thought to play animportant role in the pathogenesis of inflamed lesions. Antibacterial compounds against P. acnes were isolated from theethanol extract of Kaempferia pandurata Roxb. and identified as panduratin A and isopanduratin A. Minimum inhibitoryconcentration (MIC) and minimum bactericidal concentration (MBC) of panduratin A for P. acnes were 2 and 4µg/mL,respectively, while those of isopanduratin A were 4 and 8µg/mL, respectively. The time-dependent killing effect showed thatpanduratin A and isopanduratin A completely inhibited the growth of P. acnes at 4 and 8µg/mL in 48hr, respectively.Panduratin A and isopanduratin A demonstrated high antibacterial activities not only against P. acnes but also other skinmicroorganisms. The results suggest that panduratin A and isopanduratin A could be employed as natural antibacterial agentsto inhibit the growth of acne and skin disease causing microorganisms.

목차

Abstract
 Introduction
 Materials and Methods
 Results and Discussion
 Acknowledgments
 References

키워드

저자

• Min-Soo Song [ Department of Biotechnology, Yonsei University, Seoul 120-749, Korea ]
• Jae-Seok Shim [ Department of Biomaterials Science and Engineering, Yonsei University, Seoul 120-749, Korea ]
• Song-Hui Gwon [ Department of Biotechnology, Yonsei University, Seoul 120-749, Korea ]
• Chan-Woo Lee [ R&D Center, Amore-Pacific Corporation, Yongin, Gyeonggi 449-729, Korea ]
• Han-Sung Kim [ R&D Center, Amore-Pacific Corporation, Yongin, Gyeonggi 449-729, Korea ]
• Jae-Kwan Hwang [ Department of Biotechnology, Yonsei University, Seoul 120-749, Korea ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  Food Science and Biotechnology

• 간기

  격월간

• pISSN

  1226-7708

• 수록기간

  1992~2009

• 십진분류

  KDC 574 DDC 664