Hong Gyu Park, Jin Moon Kim, Won-Yoon Chung, Yun-Jung Yoo, Jeong-Heon Cha, Jung Mogg Kim
언어
영어(ENG)
URL
https://www.earticle.net/Article/A98218
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원문정보
초록
영어
In order to determine whether peach contains compounds to regulate adipocyte differentiation, extracts of flesh/pericarp of yellow/white peach were prepared in water, ethyl acetate (EtOAc), or n-butanol solvent and determined for effectson adipocyte differentiation in C3H10T1/2 or 3T3-L1 cells. Interestingly, none of peach extracts has statistically significantstimulatory effect on the adipocyte differentiation in C3H10T1/2. Furthermore, the presence of EtOAc extract of white peachpericarp (WPP) was found to inhibit lipid accumulation in 3T3-L1 cells both by microscopic examination of Oil Red O-stained lipid droplets and by spectrophotometric quantification of extracted stain, indicating a significant inhibitory effect onadipocyte differentiation. The inhibition of lipid accumulation was accompanied by a significant decrease in the expressionlevels of adipocyte molecular markers-peroxisome proliferator-activated receptor γ, CAAT enhancer binding protein α, andfatty acid-binding protein. Thus, this study determined that WPP EtOAc extract contains the inhibitory compound(s) onadipogenesis.
목차
Abstract Introduction Materials and Methods Results and Discussion Acknowledgments References
키워드
Prunus persicapeachobesityC3H10T1/23T3-L1
저자
Hong Gyu Park [ Department of Oral Biology, BK21 Project, Oral Science Research Center, Yonsei University College of Dentistry, Seoul 120-752, Korea ]
Jin Moon Kim [ Department of Oral Biology, BK21 Project, Oral Science Research Center, Yonsei University College of Dentistry, Seoul 120-752, Korea ]
Jung Mogg Kim [ Department of Microbiology and Institute of Biomedical Science, Hanyang University College of Medicine, Seoul 133-791, Korea ]
Won-Yoon Chung [ Department of Oral Biology, BK21 Project, Oral Science Research Center, Yonsei University College of Dentistry, Seoul 120-752, Korea ]
Yun-Jung Yoo [ Department of Oral Biology, BK21 Project, Oral Science Research Center, Yonsei University College of Dentistry, Seoul 120-752, Korea ]
Jeong-Heon Cha [ Department of Oral Biology, BK21 Project, Oral Science Research Center, Yonsei University College of Dentistry, Seoul 120-752, Korea ]
Corresponding author