Earticle

초록

영어

Adlay bran is a waste product previously thought to have no commercial value. Its methanolic extract wasfractionated using n-hexane (ABM-Hex), ethyl acetate (ABM-EtOAc), 1-butanol (ABM-BuOH), and water (ABM-H2O). TheABM-EtOAc fraction exhibited a strongest inhibition against growth of human lung cancer cell A549 and human colorectalcarcinoma cells HT-29 and COLO 205. Inhibition of cell cycle progression at G0/G1 transition, increase of cells at the sub-G1phase, and DNA ladders were observed in cells treated with ABM-EtOAc. The ABM-BuOH fraction showed the strongestinhibition of proinflammatory cytokines tumor necrosis factor (TNF)-α and interlukin (IL)-1β in stimulated RAW 264.7macrophages. Further, ABM-EtOAc and ABM-BuOH inhibited cyclooxygenase (COX)-2 expression in A549 and HT-29carcinoma cells, while COX-1 expression was not affected. These results reveal that both ABM-EtOAc and ABM-BuOH mayaid the prevention of cancers and the applications in cancer chemotherapy.

목차

Abstract
 Introduction
 Materials and Methods
 Results and Discussion
 References

키워드

저자

• Ming-Yi Lee [ Graduate Institute of Food Science and Technology, Center for Food and Biomolecules, College of Bioresources and Agriculture, National Taiwan University, Taipei 106, Taiwan ]
• Shu-Hsien Tsai [ Institute of Microbiology and Biochemistry, College of Life Science, National Taiwan University, Taipei 106, Taiwan ]
• Yueh-Hsiung Kuo [ Department of Chemistry, National Taiwan University, Taipei 106, Taiwan ]
• Wenchang Chiang [ Graduate Institute of Food Science and Technology, Center for Food and Biomolecules, College of Bioresources and Agriculture, National Taiwan University, Taipei 106, Taiwan ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  Food Science and Biotechnology

• 간기

  격월간

• pISSN

  1226-7708

• 수록기간

  1992~2009

• 십진분류

  KDC 574 DDC 664